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Human parvovirus B19: A new emerging pathogen of inflammatory

Domenii publicaţii > Ştiinţe medicale + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: C.-Thomas Bock, Karin Klingel, Susanne Aberle, Anja Duechting, Adrian Lupescu, Florian Lang and Reinhard Kandolf

Editorial: JVB 52, 2005.


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The human parvovirus B19 (PVB19), an erythrovirus causing
diverse clinical manifestations ranging from asymptomatic or
mild to more severe outcomes such as hydrops fetalis, is the
only known human pathogenic parvovirus so far. Although
enteroviruses have long been considered the most common
cause of in.ammatory cardiomyopathy, PVB19 is emerging as
a important candidate. Recent studies have indicated an
association of PVB19 with paediatric and adult in.ammatory
cardiac disease. However, whether or not PVB19 has an impact
on in.ammatory cardiomyopathy in adult patients is still
unclear. The .rst hints for a possible aetiopathogenetic role of
the PVB19-infection and the development of cardiac dysfunction
were demonstrated by molecular biology utilizing
in situ hybridization (ISH) and polymerase chain reaction
(PCR). According to available evidence, PVB19-associated
in.ammatory cardiomyopathy is characterized by infection of
endothelial cells of small intracardiac arterioles and venules,
which may be associated with endothelial dysfunction,
impairment of myocardial microcirculation, and penetration
of in.ammatory cells into the myocardium.

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Cuvinte cheie: PVB 19, inflammatory cardiomyophaty, PCR