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The significance of human platelet-activating factor acetylhydrolase in patients with chronic stable angina

Domenii publicaţii > Ştiinţe medicale + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Tanaseanu C., Moldoveanu E., Kosaka T., Tanaseanu S., Neagu M., Popescu L.M

Editorial: European Journal of Internal Medicine, 15(5), p.291-297, 2004.


Background: Inflammatory reactions within coronary atherosclerotic plaques are increasingly thought to be crucial determinants of the clinical course of patients with coronary artery disease (CAD). Platelet activating factor-acetylhydrolase (PAF-AH) is considered to reflect the ongoing inflammatory process in patients with CAD. The objective is to determine the activity of PAF-AH in patients with stable angina and its correlations to the lipoproteins level and the inflammatory status of the patient. Methods: 45 patients (documented CAD and stable angina) were investigated for PAF-AH activity, lipoproteins level and peripheral neutrophils (PMNs) activity. Results: Patients were divided in three groups according to the values of PAF-AH activity: group I (<250), group II (250-399) and group III (>400). Correlation was observed between PAF-AH activity and LDL-C/HDLch in group I and in group II. The percentage of granulocytes generating intracellular O2- is higher in group II compared with group I patients. The phagocytic activity of PMNs presents an inverse correlation with PAF-AH in group II. The high intracellular O2- generation is coupled with low extracellular release of the anion and phagocytosis impairment in group II. During the follow up period, patients in groups II and III display a worsening of the clinical state. PAF-AH activity in patients with stable angina is correlated with hyperlipemia, high PMNs activation state, and may be considered a potential predictor of vascular risk.

Cuvinte cheie: endothelial cell dysfunction, neutrophil and inflammation