Articolele autorului Elena Moldoveanu
Link la profilul stiintific al lui Elena Moldoveanu

Macrovascular disease in patients with systemic sclerosis – predictive risk factor for severe digital vasculopathy
Adiponectin levels in patients undergoing coronary stenting – Authors’ Reply,
Low basal levels of circulating adiponectin in patients undergoing coronary stenting predict in-stent restenosis, independently of basal levels of inflammatory markers: lipoprotein associated phospholipase A2, and myeloperoxidase

Objective: The aim of this study was to find a pre-interventional marker with the capacity to predict in-stent restenosis (ISR). Considering the anti-atherosclerotic role of adiponectin (APO), an adipocytokine with anti-inflammatory, anti-proliferative, anti-oxidative and anti-thrombotic properties, low plasma levels of APO might be correlated with the risk of ISR. We investigated the correlations between the plasma levels of APO and two markers

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Importance of APLA in pathogeneis of thrombotic events associated with bacterial respiratory tract infections

Abstract: Respiratory tract infections are frequently associated with thrombotic events, which contribute to severe outcome of the disease. Increased prevalence of anti phospholipid antibodies (APLA) in several bacterial infections have been reported and these autoantibodies may be important inducers of the hipercoagulable state In the present study we try to determine the prevalence of pathogenic APLA in 30 patients with bacterial respiratory tract

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Antioxidant Defense Capacity in Scleroderma Patients

Background: Oxidative stress is associated with scleroderma (systemic sclerosis) and is supposed to favor disease progression by complex effects on the vascular endothelium and on fibroblasts. Methods: Plasma oxidative process marker, thiobarbituric acid-reactive substances, and several markers of antioxidant defense capacity (plasma total antioxidant activity, serum albumin, uric acid and glutathione, superoxide dismutase and catalase) were evaluated

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Vascular endothelial growth factor, lipoprotein- associated phospholipase A2, SP-selectin and antiphospholipid antibodies, biological markers with prognostic value in pulmonary hypertension associated with chronic obstructive pulmonary disease and systemi

Objective: Pulmonary arterial hypertension (PH) is a progressive disease with a poor prognosis that ultimately leads to right ventricular failure and death. The pathogenesis of severe PH seems to be related to inflammatory responses and coagulation disturbances. Many diseases can develop PH in their course, thus aggravating their outcome. The objective was to investigate the values of vascular endothelial growth factor (VEGF), sP-selectin, lipoporotein-

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The antiphospholipid antibodies

Abstract: Antiphospholipid antibodies (APLAs) are a group ol autoantibodies directed against certain phospholipids, or their protein cofactors. Assay of APLAs is important because their interaction with anionic phospholipid-protein cofactors can generate a syndrome of hypercoagulability associated with a wide variety of thromboembolic events. This article presents the characteristics of some APLAs [anticardiolipin antibodies (aCLAs), lupus anticoagulant

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The significance of human platelet-activating factor acetylhydrolase in patients with non-insulin-dependent diabetes mellitus

Background: Non-insulin dependent diabetes mellitus (NIDDM) represents an independent risk factor for cardiovascular diseases (CVD), being characterized by a continuous low-grade inflammation and endothelial activation state. Plasma platelet - activating factor - acetylhydrolases (PAF-AHs) are a subgroup of Ca2+-independent phospholipase A2 family (also known as lipoprotein-associated phospholipases A2) that hydrolyze and inactivate the lipid mediator

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Apoptotic intensity and bcl 2 expression in patients with myelodisplastic syndrome treated with compounds which modulate proapoptotic cytokines

Excessive apoptosis has a central role in ineffective hematopoiesis in myelodysplastic syndrome (MDS). The aim of the study was to quantify apoptosis and Bcl-2 expression in patients with MDS and to use these parameters in the evaluation of treatment efficacy with compounds modulating proapoptotic cytokines. Bone marrow (BM) samples from eight MDS patients were studied: four with refractory anemia and four with refractory anemia with ringed sideroblasts.

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The IL-6 promoter polymorphism is associated with disease activitz and distability in systemic sclerosis

Systemic sclerosis (SSc) is a rare, autoimmune disease characterized by cutaneous and visceral fibrosis. Interleukin- 6 (IL-6) is involved in the pathogenesis of many immune-mediated diseases. IL-6 plays an important role in the initiation and promotion of fibrosis. The polymorphism in the position -174 (G/C) of the promoter region of the IL-6 gene (IL-6pr) may alter the expression of the gene. Complete linkage disequilibrium was observed between

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