Alexandra Deaconescu

Brown University, Providence, .

E-mail: trimite un mesaj.

Pagina web a instituţiei: http://brown.edu/research/labs/deaconescu/

Nascut(a) in: 1900

Interese: structural biology, transcription-coupled repair, protein biochemistry, electron microscopy, actin, microtubules

Details:
B.E., The Cooper Union, New York, 2001
Ph.D., The Rockefeller University, New York, 2006
Damon Runyon Cancer Research Foundation Fellow, 2008-2010
Research Associate, Howard Hughes Medical Institute, 2011-2013
Assistant Professor, Brown University, 2014-present

Publicații selectate:

* Szyk A, Deaconescu AM, Spector J, Goodman B, Valenstein ML, Ziolkowska N, Kormendi V, Grigorieff N, Roll-Mecak A, Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase., Cell, 157 (6), 2014.

* Deaconescu AM, Sevostyanova A, Artsimovitch I, Grigorieff N., Nucleotide excision repair (NER) machinery recruitment by the transcription-repair coupling factor involves unmasking of a conserved intramolecular interface, PNAS, 109, 2012.

* Szyk A, Deaconescu AM, Piszczek G, Roll-Mecak A, Tubulin tyrosine ligase structure reveals adaptation of an ancient fold to bind and modify tubulin., Nat Struct Mol Biol, 18(11), 2011.

* Okada K, Bartolini F, Deaconescu AM, Moseley JB, Dogic Z, Grigorieff N, Gundersen GG, Goode BL, Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1, JCB, 2010.

* Deaconescu AM, Savery NJ, Darst SA, The bacterial transcription-repair coupling factor, Curr Opinion Struct Biol, 17(1), 2007.

* Alexandra M. Deaconescu, Structural studies of the TRCF ATPase - coupling transcription and DNA repair in bacteria with a dsDNA-tracking motor, 2007.

* Deaconescu, AM, Chambers, AL, Smith AJ, Nickels, BE, Hochschild A, Savery NJ, Darst SA, Structural Basis for Bacterial Transcription-Coupled DNA Repair, Cell, 124, 2006.

* Deaconescu, AM and SA Darst, Crystallization and preliminary structure determination of Escherichia coli Mfd, the transcription-repair coupling factor, Acta Cryst F, F61, 2005.

* Deaconescu, A.M., Roll-Mecak, A., Bonanno, J.B., Kycia, H., Gerchman, S.E., Studier, W., Burley, S.K., X-ray Structure of Saccharomyces cerevisiae Homologous Mitochondrial Matrix Factor Hmf1, Proteins, 48, 2002.