George-Lucian Moldovan

Pennsylvania State University College of Medicine, Hershey, .

E-mail: trimite un mesaj.

Pagina web a instituţiei: http://med.psu.edu/
Pagina web personala: http://profiles.psu.edu/profiles/ProfileDetails.aspx?From=SE&Person=1889

Nascut(a) in: 1979

Interese: DNA repair, Fanconi Anemia, DNA replication, cell cycle regulation, cancer

Details:
2012-present: Assistant professor, Pennsylvania State University College of Medicine, Hershey, USA (DNA repair, genomic stability, cancer)
2007-2012: Postdoctoral research fellow, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA (Laboratory of Dr. Alan D'Andrea -DNA repair, cancer)
2001-2006: Graduate student, Max-Planck Institute of Biochemistry, Martinsried, Germany and Ludwig-Maximillians University, Munich, Germany (Laboratory of Dr. Stefan Jentsch -DNA replication, cell cycle)
2000-2001: Diploma student, Institute of Biochemistry of the Romanian Academy, Bucharest, Romania (Laboratory of Dr. Stefana Petrescu -glycosylation, protein folding)
1999: Visiting student (SOCRATES Program) at the Catholic University of Leuven, Leuven, Belgium
1997-2001: Undergraduate student, Faculty of Biology, University of Bucharest, Romania

Awards
2011-2012: Postdoctoral Fellowship from the Susan G. Komen Breast Cancer Foundation
2008-2011: Postdoctoral Fellowship from the Human Frontiers Science Program Foundation
2007: Junior Research Award of the Max-Planck Institute for Biochemistry, Munich, Germany
2006: Graduate thesis awarded 'suma cum laudae' by the Ludwig-Maximillians University, Munich, Germany

Publicații selectate:

* Moldovan GL, Dejsuphong D, Petalcorin MI, Hofmann K, Takeda S, Boulton SJ, D'Andrea AD., Inhibition of homologous recombination by the PCNA-interacting protein PARI., Molecular Cell, 45, 2012.

* Yang K, Moldovan GL, Vinciguerra P, Murai J, Takeda S, D'Andrea AD., Regulation of the Fanconi anemia pathway by a SUMO-like delivery network., Genes and Development, 25, 2011.

* Moldovan GL, D'Andrea AD., DNA damage discrimination at stalled replication forks by the Rad5 homologs HLTF and SHPRH (review), Molecular Cell, 42, 2011.

* Yang, K., Moldovan, G.L., DʼAndrea, A.D. , RAD18-dependent recruitment of SNM1A to DNA repair complexes by a Ubiquitin-binding zinc finger, Journal of Biological Chemistry, 285, 2010.

* Moldovan GL, Madhavan MV, Mirchandani KD, McCaffrey RM, Vinciguerra P, D'Andrea AD, DNA polymerase POLN participates in crosslink repair and homologous recombination, Mol Cell Biol, 30, 2010.

* Moldovan GL, D’Andrea AD, FANCD2 hurdles the DNA interstrand crosslink (review), Cell, 139, 2009.

* Moldovan GL, D'Andrea AD, How the Fanconi Anemia pathway guards the genome (review), Annual Reviews of Genetics, 43, 2009.

* Hoege C, Pfander B, Moldovan GL, Pyrowolakis G, Jentsch S., RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO, Nature, 419 (6903), 2002.

* Pfander B, Moldovan GL, Sacher M, Hoege C, Jentsch S., SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase., Nature, 436 (7049), 2005.

* Moldovan GL, Pfander B, Jentsch S, PCNA controls establishment of sister chromatid cohesion during S phase., Molecular Cell, 23 (5), 2006.

* Arakawa H, Moldovan GL, Saribasak H, Saribasak NN, Jentsch S, Buerstedde JM, A role for PCNA ubiquitination in immunoglobulin hypermutation, PLoS Biology, 4 (11), 2006.

* Moldovan GL, Pfander B, Jentsch S, PCNA, the Maestro of the Replication Fork (review), Cell, 129, 2007.