Scopul nostru este sprijinirea şi promovarea cercetării ştiinţifice şi facilitarea comunicării între cercetătorii români din întreaga lume.
Cleveland Clinic, Cleveland, Ohio, .
E-mail: trimite un mesaj.
Pagina web a instituţiei: http://www.lerner.ccf.org
Pagina web personala: www.lerner.ccf.org/cancerbio/almasan/
Nascut(a) in: 1954
Interese: biologie moleculara, cancer , apoptoza, controlul ciclului cellular
Details:
Area of general research interest: Genotoxic stress-induced signals for cell cycle control, cell death, and survival.
Current program:
DNA damage responses: radiation-regulated genes (focus on hematologic and epithelial tumors).
Integration of cellular radiation responses: apoptosis and/or cell cycle control.
Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy.
Publicații selectate:
* Chatterjee P, Plesca D, Mazumder S, Boutros J, Yannone SM, Almasan A., Defective chromatin recruitment and retention of NHEJ core components in human tumor cells expressing a Cyclin E fragment, Nucleic Acids Research, 41 (22), 2013.
* Chatterjee P, Choudhary GS, Sharma A, Singh K, Heston WD, Ciezki J, Klein EA, Almasan A, PARP inhibition sensitizes to low dose-rate radiation TMPRSS2-ERG fusion gene-expressing and PTEN-deficient prostate cancer cells., PLoS One, 8 (4), 2013.
* Sharma A, Singh K, Mazumder S, Hill BT, Kalaycio M, Almasan A., BECN1 and BIM interactions with MCL-1 determine fludarabine resistance in leukemic B cells., Cell Death Dis, 4, 2013.
* Bucur O, Stancu AL, Khosravi-Far R, Almasan A, Analysis of apoptosis methods recently used in Cancer Research and Cell Death & Disease publications., Cell Death Dis, 3, 2012.
* Ray S, Bucur O, Almasan A, Sensitization of prostate carcinoma cells to Apo2L/TRAIL by a Bcl-2 family protein inhibitor., Aoptosis, 10 (6), 2005.
* Oancea M, Mani A, Hussein MA, Almasan A, Apoptosis of multiple myeloma., Int J Hematol, 80 (3), 2004.
* Oancea M, Mazumder S, Crosby ME, Almasan A, Apoptosis assays, Methods Mol Med, 129, 2006.
* Mazumder S, Choudhary GS, Al-Harbi S, Almasan A, Mcl-1 Phosphorylation Defines ABT-737 Resistance That Can Be Overcome by Increased NOXA Expression in Leukemic B cells, Cancer Res, 72 (12), 2012.
* Singh K, Matsuyama S, Drazba JA, Almasan A., Autophagy-dependent senescence in response to DNA damage and chronic apoptotic stress, Autophagy, 8 (2), 2012.
* Al-Harbi S, Hill BT, Mazumder S, Singh K, Devecchio J, Choudhary G, Rybicki LA, Kalaycio M, Maciejewski JP, Houghton JA, Almasan A, An antiapoptotic BCL-2 family expression index predicts the response of chronic lymphocytic leukemia to ABT-737., Blood, 118 (13), 2011.
* Chen Q, Gong B, Almasan A., Distinct stages of cytochrome c release from mitochondria: evidence for a feedback amplification loop linking caspase activation to mitochondrial dysfunction in genotoxic stress induced apoptosis., Cell Death Differ, 7, 2000.
* Crosby ME, Jacobberger J, Gupta D, Macklis RM, Almasan A., E2F4 regulates a stable G2 arrest response to genotoxic stress in prostate carcinoma, Oncogene, 26, 2007.
* Almasan A, Ashkenazi A., Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy, Cytokine Growth Factor Rev, 14, 2003.
* Chen Q, Gong B, Mahmoud-Ahmed AS, Zhou A, Hsi ED, Hussein M, Almasan A., Apo2L/TRAIL and Bcl-2-related proteins regulate type I interferon-induced apoptosis in multiple myeloma., Blood, 98, 2001.
* Almasan A, Yin Y, Kelly RE, Lee EY, Bradley A, Li W, Bertino JR, Wahl GM., Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis, Proc Natl Acad Sci U S A, 92, 1995.
* Mazumder S, Plesca D, Kinter M, Almasan A., Interaction of a cyclin E fragment with Ku70 regulates Bax-mediated apoptosis, Mol Cell Biol, 27, 2007.
* Plesca D, Mazumder S, Almasan A., DNA damage response and apoptosis, Methods in Enzymolology, 446, 2008.
* Plesca D, Mazumder S, Gama V, Matsuyama S, Almasan A., A C-terminal fragment of cyclin E, generated by caspase-mediated cleavage, is degraded in the absence of a recognizable phosphodegron, J Biol Chemistry, 283, 2008.