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Simona Ruta

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"Carol Davila" University of Medicine and Pharmacy , Bucharest, .

E-mail: trimite un mesaj.

Pagina web a instituţiei: http://www.virology.ro

Nascut(a) in: 1968

Interese: HIV, hepatite parenterale, viroze emergente, oncogeneza virala

flag Details:
EDUCATION
l992 - MD from the "Carol Davila" University of Medicine and Pharmacy Bucharest, Romania
1995 - PhD in medical sciences, virology, PhD topic: "Virological and immunochemical studies in pediatric AIDS encephalopathy"
1995 -1996 Postdoctoral fellow at the WHO Collaborative Center for Rickettsial Reference and Research, Marseille Faculty of Medicine.
1998- Visiting researcher at Baylor College of Medicine, Center for AIDS Research and Texas Children Hospital, Houston, Texas, USA

PRESENT POSITION:
Professor of Virology, "Carol Davila" University of Medicine, Bucharest, Romania
Senior researcher and Scientific Director, HIV/AIDS International Laboratory Center of Excellence, Baylor International Paediatric AIDS Initiative, "St. S. Nicolau" Institute of Virology, Bucharest, Romania

Main research fields:
Molecular epidemiology studies on the pediatric HIV epidemics in Romania; Antigenic diversity and replicative fitness of different HIV subtypes ;
Virological studies in the pediatric AIDS encephalopathy; Molecular diagnosis in malignant opportunistic diseases involving EBV, HPV and HHV8 in HIV infected individuals;
Studies on parenterally transmitted viral hepatitis in the general population and in selected risk groups
Recognision and cell signaling mechanisms implied in macrophages infections with different germs
West Nile encephalitis as an emerging viral disease; the role of the blood brain barrier in viral encephalitis

Projects
Co-investigator in 7 international projects, Director for 16 national research projects and partener in 30 research projects (Ministry of Research, Ministry of Health, Romanian Academy).

Awards
AWARDS:
1996- "Constantin Levaditi" prize of the Medical Sciences Academy of Romania for the PhD thesis (Pediatric HIV encephalopathy);
2000- "St. S. Nicolau" prize from the Romanian Academy for the studies dedicated to the West Nile meningoencephalitis

Advisory Council Member IUMS-International Union Of Microbiological Societies, Virology Division (2006-present)
Selected Publications
1.Ruta S, Cernescu C, Influence of social changes on the evolution of HIV infection in Romania International Journal of Environmental Studies, 2008,65, 4, 501-513, DOI: 10.1080/00207230802291629
2.Cernescu C, Ruta S, Romanian experience in post-event environment surveillance for West Nile Virus infectionsInternational Journal of Environmental Studies, 2008, 65, 4, 529-538, DOI: 10.1080/00207230802259691
3.Ruta S, Manolescu L, Sultana C, Cernescu C. Serial testing of liver chemistries and HBV DNA during antiretroviral treatment in patients with HIV/HBV co-infection Proc. Rom. Academy, serie B, 2007, 9, 1-2, 23-26,
4.Ruta S, Cernescu C, Factors responsible for the high frequency of West Nile neuroinvasive disease in recent urban outbreaks, Proc. Rom. Academy, serie B, 2007, 9, 1-2, ISSN 1454-8267
5.Bleotu C., Diaconu CC, Chivu M, Alexiu I, Ruta SM, Cernescu C. Evaluation of TV cell line viral susceptibility using conventional cell culture techniques Central European Journal of Medicine, 1, 12-22, 2006.
6.Ruta SM, Matusa RF, Cernescu C, Low frequency of immune reconstitution inflammatory syndrome (IRIS) in patients with old HBV/HIV co-infection Proc. Rom. Academy. serie B, 2006, 8, 2-3,63-67
7.Ruta SM, Matusa RF; Sultana C, Manolescu L, Kozinetz CA, Kline MW, Cernescu C High Prevalence of Hepatitis B Virus Markers in Romanian Adolescents With HIV Infection, MedGenMed, 2005, 7, 1, 68-72
8.Kozinetz C, Matusa R, Ruta SM, Cernescu C, Hacker C, Cazacu A. Alternative to HIV-RNA and CD4 count to monitor HIV disease progression: A prospective cohort study in Romania. J Med Virol. 2005;77(2):159-163
9.Cernescu C. Ruta SM. About the founder effect of Human Immunodeficiency Virus type 1 subtype F in Romanian AIDS epidemic. Proc. Rom. Academy serie B, 2005, 7, 1, 55-60.
10.Diaconu CC., Tone M., Ruta SM., Bleotu C., Cernescu C, Volanschi E Spectral study of the interaction of hemin with some HIV-1 V3 synthetic peptides. Proc. Rom. Academy. serie B, 2005, 7, 1, 15-23 .
11.Ruta SM, Cernescu C Health related quality of life in symptomatic HIV infected adolescents, Proc. Rom. Academy. serie B, 2005, 7, 2-3,135-141
12.Ruta SM, Cernescu C SWOT analysis of HIV/AIDS research efforts in Romania Proc. Rom. Academy. serie B, 2005, 7,2, 129-135.
13.Ruta SM, Duiculescu D, Ene L, Toni M, Dache A, Cernescu C. Challenges to delivering end of life care for adolescents with AIDS Proc. Roum. Academy serie B, 2004, 3, 191-7.
14.Diaconu CC, Bleotu C, Chivu M, Alexiu I, Petrusca D, Anton G., Achim R., Ruta SM, Cernescu C. The development of larger cells that spontaneously escape senescence- a step during the immortalization of a human cancer cell line. J. Cell. Mol. Med. 8 (1), pp. 93-101, 2004.
15.CN Zaharia, A. Petrescu, Ruta SM, C. Cernescu Analysis of influenza surveillance data in South Eastern Romania-season 2001-2002 Proc. Rom. Acad, Series B, 2, pp. 113-116, 2002
16.Ruta SM, Abagiu A., Cernescu C. Acute viral hepatitis in correctional facilities, J. Clin. Virol, 22, 2,173, 2001.
17.Cernescu C, Nedelcu I., Tardei G., Ruta SM, Tsai T. Continued transmission of West Nile virus to humans in southeastern Romania 1997 - 1998. J Inf Dis,18 (2), pp. 710-2, 2000
18.Tardei G, Ruta SM., Chitu V., Rossi C. A., Tsai T.F., Cernescu C. Evaluation of IgM and IgG Enzyme Immunoassay in the serologic diagnosis of West Nile virus infection, J. Clin. Microb., 38, 6, pp. 2232-2239, 2000.
19.Ruta SM., C. Diaconu, C. Grancea, C. Cernescu, A survey of hepatitis B virus infection in children from Romanian orphanages, Proc. Rom. Acad.Series B; 1, pp. 67-71, 1999
20.Ruta SM, N. Plasman, Y. Zaffran, C. Capo, J.L. Mege, B. Vray Trypanosoma cruzi-induced tyrosine phosphorilation in murine peritoneal macrophages. Parasitol. Res. 82, pp. 481-482, 1996.
21.Y. Zaffran, J.C. Escallier, Ruta SM , C. Capo, J.L. Mege; Zymosan-triggered association of tyrosyne phosphoproteins and lyn kinase with cytoskeleton in human monocytes. J. Immunol., 154, 7, pp. 3488-3500, 1995.
22.Ruta SM, Cernescu C. Syncytium forming capacity of HIV 1 strains is inhibited by pretreatment of CD 4 expressing cells with 3'-azido-3'-deoxythymidine but not by alpha interferon. Rev. roum. Virol., 45, pp. 3-4, 1994
23.Cernescu C., Tardei G., Necula A., Ruta SM, C.P. Pau. The serologic significance of F viral genotype for Human Immunodeficiency Virus type 1 epidemic. J Inf. Dis.,170, pp. 1043-44, 1994.

NUMBER OF COMMUNICATIONS TO SCIENTIFIC MEETINGS: 108
NUMBER OF BOOKS and MONOGRAPHS: 6-most recent titles:
1.C. Cernescu, Ruta SM "Laboratory biosafety manual" (Manual pentru bioprotectie in laborator), in romanian Studii si cercetari de virusologie, , 26(2), 1996.
2.C. Cernescu, Ruta S.M. "Practical viral diagnosis" (Practica diagnosticului virusologic,), in romanian, edit. Concept Pbl, 1997
3.Ruta S.M., C. Cernescu, "AIDS -the antiretroviral treatment" (SIDA-Tratamentul cu antiretrovirale), in romanian, edit Concept Pbl, 1998.
4.C. Cernescu , Ruta SM "Clinical Virology manual" ( Curs concis de virusologie) in romanian Editura Universitara "Carol Davila" , 2002, 2003
5.C. Cernescu, Ruta SM "Antiviral drugs" (Medicamente antivirale), in romanian Editura Universitara "Carol Davila", 2003.
6.C. Cernescu, Ruta SM "Control and prevention of outbreaks caused by viral agents of bioterrorism" (Progrese in controlul si prevenirea virozelor cu potential bioterorist), Editura Universitara "Carol Davila", 2004.

Publicații selectate:

* Tardei G, Ruta S., Chitu V., Rossi C. A., Tsai T.F., Cernescu C., Evaluation of IgM and IgG Enzyme Immunoassay in the serologic diagnosis of West Nile virus infection, J. Clin. Microb, 38, 6, 2000.

* Cernescu C, Nedelcu I., Tardei G., Ruta S, Tsai T. , Continued transmission of West Nile virus to humans in southeastern Romania 1997 - 1998. , J Inf Dis, 18 (2), 2000.

* Diaconu CC, Bleotu C, Chivu M, Alexiu I, Petrusca D, Anton G., Achim R., Ruta SM, Cernescu C., The development of larger cells that spontaneously escape senescence- a step during the immortalization of a human cancer cell line, J. Cell. Mol. Med., 8 (1), 2004.

* Kozinetz C, Matusa R, Ruta SM, Cernescu C, Hacker C, Cazacu A. , Alternative to HIV-RNA and CD4 count to monitor HIV disease progression: A prospective cohort study in Romania. , J Med Virol. 2005, 77(2), 2005.

* Ruta SM, Matusa RF; Sultana C, Manolescu L, Kozinetz CA, Kline MW, Cernescu C, High Prevalence of Hepatitis B Virus Markers in Romanian Adolescents With HIV Infection, MedGenMed, 7, 1, 2005.

* Bleotu C., Diaconu CC, Chivu M, Alexiu I, Ruta S, Cernescu C. , Evaluation of TV cell line viral susceptibility using conventional cell culture techniques , , Central European Journal of Medicine, 1, 1, 2006.

* Cernescu C, Ruta S, Romanian experience in post-event environment surveillance for West Nile virus infections , International Journal of Environmental Studies, Volume 65 Issue 4, 2008.

* Ruta S, Cernescu C, Influence of social changes on the evolution of HIV infection in Romania, International Journal of Environmental Studies, Volume 65 Issue 4,, 2008.