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Adrian Nicolescu

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Queen's University, Faculty of Health Sciences, Kingston, Canada.

E-mail: trimite un mesaj.

Pagina web a instituţiei: http://www.queensu.ca
Pagina web personala: http://www.researcherid.com/rid/B-9735-2011

Urmareste linkul ResearcherID pentru toate articolele cercetatorului: B-9735-2011. Tabelul detaliat al articolelor este in josul paginii.

Nascut(a) in: 1967

Interese: farmacoterapia si toxicologie cardiovasculara si neurologica, farmacie clinica, proteomica

flag Detalii:
Stresul oxidativ celular este prezent in numeroase patologii ca de exemplu in boli neurodegenerative, soc septic, infarct miocardic, accident vascular cerebral acut sau ateroscleroza. Oxidul de azot (NO) este un radical liber produs de celule. NO indeplineste roluri importante in modularea tonusului vascular, in apararea imunitara, in fiziologia aparatului reproducator sau in memorie. Studii au demonstrat ca NO poate contracara efectele daunatoare ale stresului oxidativ fie direct prin actiunea antioxidanta, fie indirect prin reactii de semnalizare intracelulara (de ex. sistemul guanilat ciclaza solubila/GMP ciclic). Pe de alta parte, NO contribuie la stresul oxidativ prin intermediul peroxinitritului, anion format in urma reactiei extrem de rapide dintre NO si radical anionul superoxid.

flag Details:
Oxidative stress is an important component of many pathologies, including neurodegeneration, septic shock, stroke, myocardial infarction, or atherosclerosis. Nitric oxide (NO) is free radical gas that is synthesized by living cells. NO performs important roles in vascular relaxation, immune defense, sexual function and memory. NO has been shown to inhibit oxidative stress, either directly (i.e., antioxidant action) or via cellular signaling pathways (e.g., soluble guanylate cyclase/cGMP pathway). NO has also been shown to contribute to oxidative stress through peroxynitrite, the product of the diffusion-controlled reaction between NO and superoxide radical anion.

Publicații selectate:

* Mircioiu C., Voicu V. A., Ionescu M., Miron D. S., Radulescu F. S., Nicolescu A. C, Evaluation of in vitro absorption, decontamination and desorption of organophosphorous compounds from skin and synthetic membranes, Toxicol. Lett., 219 (2), 2013.

* Richardson D.S., Rodrigues D.M., Hyndman B.D., Crupi M.J., Nicolescu A.C., Mulligan L.M, Alternative splicing results in RET isoforms with distinct trafficking properties, Mol. Biol. Cell., 23(19), 2012.

* Wagner S.M., Zhu S.J., Nicolescu A.C., Mulligan L.M, Molecular mechanisms of RET receptor-mediated oncogenesis in multiple endocrine neoplasia 2, Clinics, 67, 2012.

* Nicolescu A. C, Mechanisms of nitric oxide release from organic nitrates and nitrites: implications on the activation of soluble guanylyl cyclase and inhibition of lipid peroxidation [dissertation], National Library of Canada, Ottawa, Queen's University, Theses (Ph.D.), 2004.

* Hatieganu E.M, Nicolescu A., Gutu M., Chimie farmaceutica I, Editura Medicala, Bucuresti, ISBN 973-39-0385, 1999.

* Nicolescu A.C., Mircioiu C, Inhibition of a calcium-dependent cysteine protease by doxycycline, Farmacia, 58(2), 2010.

* Nicolescu A.C., Chow A.K., Garcia M.E., Viappiani S., Ali M.A., Holt A., Schulz R, Matrix metalloproteinase-2 modification in relation to myocardial ischemia-reperfusion injury, Can. J. Cardiol., 24, 2008.

* Nicolescu A.C., Viappiani S., Holt A., Schulz R, Post-translational modification of matrix metalloproteinase-2 by peroxynitrite, FASEB J., 22, 2008.

* Nicolescu A.C., Holt A., Kandasamy A.D., Pacher P., Schulz R, Inhibition of matrix metalloproteinase-2 by PARP inhibitors, Biochem. Biophys. Res. Commun., 387(4), 2009.

* Viappiani S., Nicolescu A.C., Holt A., Sawicki G., Crawford B.D., León H., van Mulligen T., Schulz R, Activation and modulation of 72kDa matrix metalloproteinase-2 by peroxynitrite and glutathione, Biochem. Pharmacol., 77(5), 2009.

* Nicolescu A.C., Thatcher G.R., Bennett B.M, Soluble guanylate cyclase activation by a series of aryl disulfanyl dinitrates, Abstr. Pap. Am. Chem. Soc., 229, 2006.

* Nicolescu A.C., Brien J.F., Racz W.J., Massey T.E, Investigation of prevention of amiodarone- and desethylamiodarone-toxicity in human peripheral lung epithelial cells HPL1A, Toxicologist, 84(S-1), 2005.

* Nicolescu A.C., Ji Y., Comeau J.L., Hill B.C., Takahashi T., Racz W.J., Massey T.E, Direct mitochondrial dysfunction precedes reactive oxygen species production in amiodarone-induced toxicity in human peripheral lung epithelial HPL1A cells, Toxicol. Appl. Pharmacol, 227(3), 2008.

* Nicolescu A.C., Hill B.C., Brien J.F., Racz W.J., Massey T.E, Amiodarone-induced cytotoxicity: Link to mitochondrial dysfunction and labile iron involvement, Chem. Res. Toxicol., 19(12), 2006.

* Nicolescu A.C., Comeau J.L., Hill B.C., Bedard L.L., Takahashi T., Brien J.F., Racz W.J., Massey T.E, Aryl radical involvement in amiodarone-induced pulmonary toxicity: Investigation of protection by spin-trapping nitrones, Toxicol. Appl. Pharmacol., 220(1), 2007.

* Nicolescu A.C., Li Q., Brown L., Thatcher G.R, Nitroxidation, nitration, and oxidation of a BODIPY fluorophore by RNOS and ROS, Nitric Oxide, 15(2), 2006.

* Thatcher G.R., Nicolescu A.C., Bennett B.M., Toader V, Nitrates and NO release: contemporary aspects in biological and medicinal chemistry, Free Radical Biol. Med., 37(8), 2004.

* Nicolescu A.C., Reynolds J.N., Barclay L.R., Thatcher G.R, Organic nitrites and NO: inhibition of lipid peroxidation and radical reactions, Chem. Res. Toxicol., 17 (2), 2004.

* Smith S., Nicolescu A.C., Dringenberg H., Thatcher G.R., Reynolds J.N, Cognition enhancement and neuroprotection with a novel nitrate ester, FASEB J., 14(8), 2000.

* Toader V., Artz J.D., Nicolescu A.C., Zavorin S.I., Bennett B.M., Thatcher G.R, Chemistry and biology of nitrate esters, Nitric Oxide, 6(4), 2002.

* Nicolescu A.C., Zavorin S.I., Toader V., Reynolds J.N., Thatcher G.R, Antioxidant activity of nitrates and nitrites, Nitric Oxide, 6(4), 2002.

* Nicolescu A.C., Reynolds J.N., Zavorin S.I., Thatcher G.R, No single strategy for the mechanism of nitric oxide release from organic nitrates and nitrites, 39th IUPAC Congress and 86th Conference of the Canadian Society for Chemistry, 2003.

* Toader V., Xu X., Nicolescu A.C., Yu L., Bolton J.L., Thatcher G.R, Nitrosation, nitration, and autoxidation of the selective estrogen receptor modulator raloxifene by nitric oxide, peroxynitrite, and reactive nitrogen/oxygen species., Chem. Res. Toxicol., 16(10), 2003.

* Nicolescu, A.C., Zavorin, S.I., Reynolds, J.N., Thatcher, G.R, Inhibition of lipid peroxidation in synaptosomes and liposomes by nitrates and nitrites, Chem. Res.Toxicol., 15 (7), 2002.

* Zavorin, S.I., Artz, J.D., Dumitrascu, A., Nicolescu, A.C., Scutaru, D., Smith, S.V., Thatcher, G.R, Nitrate esters as nitric oxide donors: SS-nitrates, Org. Lett., 3(8), 2001.

* Nicolescu, A.C., Toader, V., Zavorin, S.I., Artz, J.D., Smith, S.V., Reynolds, J.N., Thatcher, G.R, Inhibition of lipid peroxidation by nitrates and nitrites, Proc. Soc. Neurosci., 31, 2001.

Mai jos este tabelul ResearcherID/B-9735-2011 pentru toate articolele cercetatorului Adrian Nicolescu: