Liviu Constantin Ciobanu

Centre de Recherche en Endocrinologie Moléculaire et Oncologie, Sainte Foy, Québec, .

E-mail: trimite un mesaj.

Pagina web a instituţiei: http://www.crchul.ulaval.ca

Nascut(a) in: 1970

Interese: chimie organica, sinteza organica combinatorie si pe suport solid

Detalii:
Sinteza de compusi organici steroidieni si nonsteroidieni cu potential terapeutic pentru maladii hormono-dependente: cancerul de sân si de prostata. Metodologii de sinteza combinatorie si pe suport solid aplicabile in chimia steroizilor.

Details:
Synthesis of steroidal and nonsteroidal compounds as potential inhibitors of steroidogenic enzymes involved in hormone-dependent diseases such as breast and prostate cancers. Combinatorial and solid-phase synthetic methodologies applicable in steroid chemistry.

Publicații selectate:

* Ciobanu LC, Luu-The V, Poirier D, Nonsteroidal compounds designed to mimic potent steroid sulfatase inhibitors, J Steroid Biochem Mol Biol, Mar;80(3), 2002.

* Ciobanu LC, Boivin RP, Luu-The V, Poirier D, Synthesis and steroid sulphatase inhibitory activity of C19- and C21-steroidal derivatives bearing a benzyl-inhibiting group, Eur J Med Chem, Jul-Aug;36(7-8):, 2001.

* Ciobanu LC, Maltais R, Poirier D., The sulfamate functional group as a new anchor for solid-phase organic synthesis, Organic Letters, Feb 24 2(4), 2000.

* Ciobanu LC, Boivin RP, Luu-The V, Labrie F, Poirier D., Potent inhibition of steroid sulfatase activity by 3-O-sulfamate 17alpha-benzyl(or 4'-tert-butylbenzyl)estra-1,3,5(10)-trienes: combination of two substituents at positions C3 and C17-alpha of estradiol., J Med Chem., Jun 17;42(12), 1999.