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Structure-based design of protein tyrosine phosphatase-1B inhibitors

Domenii publicaţii > Chimie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Black, Emma; Breed, Jason; Breeze, Alexander L.; Embrey, Kevin; Garcia, Robert; Gero, Thomas W.; Godfrey, Linda; Kenny, Peter W.; Morley, Andrew D.; Minshull, Claire A.; Pannifer, Andrew D.; Read, Jon; Rees, Amanda; Russell, Daniel J.; Toader, Dorin; Tuck

Editorial: Bioorganic & Medicinal Chemistry Letters, 15(10), p.2503-2507, 2005.

Rezumat:

Using structure-based design, a new class of inhibitors of protein tyrosine phosphatase-1B (PTP1B) has been identified, which incorporate the 1,2,5-thiadiazolidin-3-one-1,1-dioxide template

Cuvinte cheie: phosphatases, drug design