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Photodynamic therapy studies on brain tumors using nitrogen pulsed lasers

Domenii publicaţii > Chimie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Pascu, Mihail L.; Popescu, Alina; Danaila, Leon; Carp, N.; Ion, Rodica-Mariana; Pascu, Mihaela O.; Staicu, Angela

Editorial: Proc.SPIE, 4166, p.138-144, 2000.

Rezumat:

The spectroscopic characterization of synthetic porphyrins such as TPP, TSPP, ZnTSPP, etc. is reported, namely: absorption and laser induced fluorescence spectra in different solvents. Results about the photo toxicity of such photosensitizers in 5 percent DMSO in ns NaCl 0.9 percent on rats are shown proving the good acceptance of the solutions by the rats organisms with immediate perspectives for application on human patients. The second main line of experiments was devoted to the measurements of the irreversible modifications induced in the cell structure of the brain malignant tumors – impregnated with photosensitizers solutions – by the nitrogen pulsed laser radiation. ‘In vitro’ samples of brain tumor tissue were prelevated and impregnated with photosensitizer solutions during 1 hour to 48 hours. The samples were treated and kept so that before and after exposures to the laser beams the modifications due to other factors than the laser irradiation be avoided or minimized. The exposures to laser radiation were made along time intervals form 3 minutes to more than 1 hour. Irreversible modifications at cellular level following the interaction of impregnated cells with laser radiation were evidenced by optical microscopy. Concluding remarks are made about further ‘in vivo’ application on human patients.

Cuvinte cheie: photodynamic therapy, lasers, porphyrins