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Effect of chemical compositions and topographical features of collagen biofilms on cell response

Domenii publicaţii > Chimie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Zgirian G., Iovu H., Ionescu-Bujor I., Popescu R., Demetrescu I., Iordachescu D.

Editorial: MOLECULAR CRYSTALS AND LIQUID CRYSTALS, 448, p.83-94, 2006.


In this work a range of hybrid multi-component polymer biofilms with various collagen content, synthetic poly-alcohols and hydroxiapatite were obtained , characterized and discussed . Physicochemical, topographical features and biocompatibility of biofilms were performed using as investigations: gel chromatography and viscosimetric method for molecular weight determinations; liquid porosimetry, surface analysis type Atomic Force Microscopy (AFM) and cytotoxicity test for cell culture. This study provides evidence that the cell growth is directly affected by biofilms composition, structure and topographical features of surface, the molecular average weight, the cross-linking, solubility, number and characteristics components of hybrid composites, and roughness of films being in a specific relationship with cell adhesion

Cuvinte cheie: colagen, hidroxiapatita, caracteristici topografice // collagen, hydroxiapatite, topographical features