Autori: G. . Doros, M. Puiu, A. Popoiu, M. Gafencu, M. Serban
Editorial: European Journal of Human Genetics, 2005.
The aim of the study is to present the evolution of the congenital heart defects(CHD) in children from Timisoara, over a period of 11 years, time in which we felt the consequences of the nuclear accident in Chernobyl-Russia and the war in Yugoslavia, country nearby.The study was done on a cohort of 1113 children with CHD, classified in two groups: 226 children between 1990-1994 and 887 children between 1995-2001.The number of CHD between first and second group arise 3,92 times; the noncyanotic CHD arise 4 times and the cyanotic CHD arise 3 times.From the noncyanotic CHD, left to right shunts arise 3,5 times, complex malformations arise 7,5 times and obstructive CHD 5,4 times. In the first group, 90,7% were noncyanotic, 9,3% were cyanotic.The noncyanotic CHD were composed of: 83,40% left to right shunt, 8,30% complex CHD and 8,30% obstructive CHD. From the left to right shunt malformations, the dominant were: ASD (55,12%), VSD (20,48%) and PDA (7,8%).In the second group, 92, 67% were noncyanotic and 7,32% were cyanotic.The noncyanotic CHD were composed of: 72,99%, left to right shunt, 15,69% complex CHD and 11,32% obstructive CHD.The dominant left to right shunts were: ASD (40,75%), VSD (19,82%), and PDA (12,40%). The number of CHD arise 3,9 times in the second period vs the first one, most of the cases registered between 1997-2000.The noncyanotic CHD were dominant in both groups.The most important rising in complex CHD were in the second group, as a result of the teratogenic factors to which Romania was exposed.
Cuvinte cheie: congenital heart defects, child, teratogenic