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Therapeutic application of long-circulating liposomal glucocorticoids in auto-immune diseases and cancer.

Domenii publicaţii > Ştiinţe medicale + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Schiffelers, R. M., Banciu, M., Metselaar, J. M., Storm, G.

Editorial: J Liposome Res., 16 (3), p.185-194., 2006.


Glucorticoids are potent drugs that have a multitude of pharmacological actions both
at genomic and non-genomic levels. Many of the diseases in which glucorticoids are
routinely administered are featured by angiogenesis and enhanced capillary permeability,
permitting targeted delivery using long-circulating drug delivery systems. By
encapsulation of glucorticoids in long-circulating liposomes, drug levels at the site of
the pathology are markedly higher, increasing and prolonging therapeutic efficacy in
models of rheumatoid arthritis, multiple sclerosis, and cancer.

Cuvinte cheie: liposomes, glucocorticoids, auto-immune diseases, cancer, angiogenesis