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Hepatitis B virus reactivation after a resolutive acute hepatitis leading to a diagnosis of T cell lymphoma.

Domenii publicaţii > Ştiinţe medicale + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Negreanu L, Baty G, Dubois F, de Muret A, Bacq Y.

Editorial: Elsevier, Dig Liver Dis. 2009 Jul;41(7):e39-41. Epub 2008 Sep 25., 2009.


A case of hepatitis B virus reactivation leading to the diagnosis of a T cell lymphoma is reported. A 66-year-old woman with a past history (10 years before) of spontaneously recovered acute hepatitis B (with disappearance of serum hepatitis B surface antigen and appearance of anti-HBs), has been referred for hepatologic consultation for acute hepatitis. The patient was found positive again for hepatitis B surface antigen as well HBeAg and hepatitis B virus DNA. No other cause of liver disease was identified and a diagnosis of spontaneous hepatitis B virus reactivation was made. Five months later a peripheral T cell lymphoma was diagnosed. This unusual case confirms that natural immunity is not protective against hepatitis B virus reactivation and shows that such hepatitis B virus reactivation may precede the usual clinical manifestations of a peripheral T cell lymphoma.

Cuvinte cheie: hepatitis, reactivation, lymphoma