Facing the growing economic significance of carotenoids, much interest has been devoted to new supplies of this type of pigment. In particular, the development of carotenoid-producing microorganisms is new regarded as a competitive pathway since they can provide natural and original pigments such as torularhodin and β-carotene produced by Rhodotorula glutinis (Sakaki et al. 2000, Bhosale & Gadre 2001) or astaxanthin from Phaffia rhodozyma (Yamane

Torularhodin (scheme 1) is the unique carotenoid with a terminal carboxylic group considered now-a-days as a powerful antioxidant to be included in food and drugs formulations. The improving of this carotenoid formation in an aerobic bioprocess with the red yeast Sporobolomyces ruberrimus, isolated in the National Superior School of Agriculture and Food Industries laboratory, includes the use of technical glycerol, main by-product from the commercial

Objective The paper presents the experimental research to redesign the separation stage of a bacterial immunomodulator of pharmaceutical use, to be integrated into the GMP (Good Manufacturing Practice) small scale bioproduct manufacture aseptic, closed flow. It is to study: the separation characteristics for each technological operation, the membrane regeneration capacity and to evaluate: the needed membrane aria and the period of working time for

Bioprocesses are appreciated as difficult to control because their dynamic behavior is highly nonlinear and time varying, in particular, when they are operating in fed batch mode. The research objective of this study was to develop an appropriate control method for a complex bioprocess and to implement it on a laboratory plant. Hence, an intelligent control structure has been designed in order to produce biomass and to maximize the specific growth