Quercetin interaction with dsDNA was investigated electrochemically using wo types of DNA biosensor in order to evaluate the occurrence of DNA damage caused by oxidized quercetin. The results showed that quercetin binds to dsDNA where it can undergo oxidation. The radicals formed during quercetin oxidation cause breaks of the hydrogen bonds in the dsDNA finally giving rise to 8-oxoguanine since the DNA guanosine and adenosine nucleotides in contact

The present study aims to investigate the quercetin–deoxyribonucleic acid (DNA) interaction occurring in bulk solution either electrochemically using differential pulse voltammetry or spectrophotometrically, in order to explain the possible DNA-damaging activity of quercetin. A very weak interaction between quercetin and DNA in solution was found to take place. However, since extensive quercetininduced DNA damage via reaction with Cu(II) has been

Oxidative stress can be caused by in vivo chemical generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) besides ultraviolet and ionizing radiation. Recently, DNA damage due to RNS became an interesting subject since high nitric oxide (NO) concentration in cells was reported to produce genotoxic effects. The DNA biosensor has been shown to represent a powerful tool for the study of biomolecular interaction mechanisms. The