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Publicatii proprii
3D-QSAR study indicates an enhancing effect of membrane ions on psychiatric drugs targeting serotonin receptor 5-HT1A
Antidepressants and antipsychotics are psychiatric agents used for the treatment of various types of psychiatric diseases. Although currently among the most commonly prescribed drugs, their effectiveness and adverse effects are the topic of many studies and controversial claims. Here we generate QSAR models based on compounds series including 20 drugs recommended for two critical psychiatric diseases: depression and schizophrenia and we use these
Read moreAnalyses of gating thermodynamics and effects of deletions in the mechanosensitive channel TREK-1: comparisons with structural models
TREK-1, a mechanosensitive K channel from the two-pore family (K(2)P), is involved in protective regulation of the resting potential in CNS neurons and other tissues. The structure of TREK-1 and the basis of its sensitivity to stretch and variety of lipid-soluble factors remain unknown. Using existing K channel structures as modeling templates, TREK-1 was envisioned as a two-fold symmetrical complex with the gate formed primarily by the centrally
Read moreStructural models of TREK channels and their gating mechanism
Mechanosensitive TREK channels belong to the family of K2P channels, a family of widely distributed, well modulated channels that uniquely have two similar or identical subunits, each with two TM1-P-TM2 motifs. Our goal is to build viable structural models of TREK channels, as representatives of K2P channels family. The structures available to be used as templates belong to the 2TM channels superfamily. These have low sequence similarity and different
Read moreComparison Between Radar Estimated and Rain Gauge Measured Precipitation in the Moldavian Plateau
Heavy rainfall events have produced significant damages and casualties in the Moldavian Plateau (Romania) in the last decades. Such phenomena are characterized by large spatial and temporal variations, and the forecast of their occurrence is thus very challenging. This study aims to compare the radar estimations and the rain gauge measurements, in order to improve the quantitative precipitation estimation (QPE) in the area of interest. The research
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