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Leonard Girnita

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Karolinska Institute, Stockholm, .

E-mail: trimite un mesaj.


Pagina web personala: http://www.ki.se

Nascut(a) in: 1967

Interese: patologie celulara si moleculara, semnalizare celulara, cancer

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Professional preparation

• 2002: PhD in Pathology, Cytology and Experimental Pathology, Cancer Center Karolinska, Karolinska Institute, Stockholm, Sweden
• 1999: Board Certified Specialist in Anatomic and Surgical Pathology, Bucharest, Romania
• 1995: MD License, Bucharest, Romania
• 1995: MD, Craiova Medical University, Craiova, Romania

Appointments


• July 2006-present, Senior researcher/professor, Department of Oncology/Pathology, Karolinska Institute
• Consultant pathologist, StErik's Eye Hospital 25%
• 2005 (February-April) Visiting researcher, laboratory of receptor biology ( Robert J. Lefkowitz) Howard Hughes Medical Institute, Duke University, Durham, USA
• 2002-present postdoctoral training (100% research)
Karolinska Institute, Cancer Center Karolinska, Department of Cellular and Molecular Tumor Pathology (postdoctoral position from Cancerföreningen in Stockholm)
• 1999- 2002 Postgraduate Education
PhD, Cellular and Molecular Tumor Pathology, Department of Oncology/Pathology, Cancer Center Karolinska, Karolinska Institute, Stockholm, Sweden
• 1995-1999 Postgraduate Medical Training
Internship and Residency: Anatomic and Clinical Pathology, Craiova University Hospital, Craiova, Romania

Honors and awards

• Young investigator award, Cancer Centrum Karolinska, 2000.
• "Satsning på juniora forskare" (Young investigator award), Karolinska Institute 2003.
• European Association for Cancer Research Fellowship Award 2005.
• American Association for Cancer Research-Pezcoller Foundation Award 2005
• Keystone Symposia Scholarship Award 2005
• EACR Young Cancer Researcher "Highly Commended"Award 2005
• "Satsning på juniora forskare" Karolinska Institute 2006.
Teaching and PhD supervision.

Publicații selectate:

* Girnita L, Shenoy SK, Sehat B, Vasilcanu R, Girnita A, Lefkowitz RJ, Larsson O., {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase., J Biol Chem. 2005 Jul 1;280(26):24412-9. Epub 2005 May 3., 2005.

* Girnita L, Girnita A, Larsson O., Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor., Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8247-52. Epub 2003 Jun 23., 2003.

* Stromberg T, Ekman S, Girnita L, Dimberg LY, Larsson O, Axelson M, Lennartsson J, Hellman U, Carlson K, Osterborg A, Vanderkerken K, Nilsson K, Jernberg-Wiklund H., IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cells., Blood. 2006 Jan 15;107(2):669-78. Epub 2005 Sep 15, 2006.

* Vasilcanu D, Weng WH, Girnita A, Lui WO, Vasilcanu R, Axelson M, Larsson O, Larsson C, Girnita L., The insulin-like growth factor-1 receptor inhibitor PPP produces only very limited resistance in tumor cells exposed to long-term selection., Oncogene. 2006 May 25;25(22):3186-95., 2006.

* Girnita A, All-Ericsson C, Economou MA, Astrom K, Axelson M, Seregard S, Larsson O, Girnita L., The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of uveal melanoma cells., Clin Cancer Res. 2006 Feb 15;12(4):1383-91., 2006.