Radu Silaghi-Dumitrescu

Universitatea 'Babes-Bolyai', University of Essex, Cluj, .

E-mail: trimite un mesaj.

Pagina web a instituţiei: http://www.chem.ubbcluj.ro
Pagina web personala: http://chem.ubbcluj.ro/pagini/biochimie/radu/rsilaghi.htm

Nascut(a) in: 1974

Interese: bioinorganic, oxidative stress, nitrosative stress, blood substitutes, metalloproteins, computational chemistry

Details:
Main research interest: small molecule activation by metalloproteins and model systems. Examples: dioxygen and peroxide activation (peroxidases, oxidases, oxygenases, cytochromes P450), nitric oxide and nitrite reduction/oxidation, nitrile hydrolysis, oxidative stress (superoxide dismutase, superoxide reductase, peroxidase, catalase), nitrosative stress (NO reductase, NO dioxygenase), dioxygen carriers, blood substitutes. Other interests: biotransformations, arsenic chemistry.

Publicații selectate:

* Silaghi-Dumitrescu R, Reeder BJ, Nicholls P, Cooper CE, Wilson MT, Ferryl haem protonation gates peroxidatic reactivity in globins, Biochemical Journal, 403(3), 2007.

* Svistunenko DA, Reeder BJ, Wankasi MM, Silaghi-Dumitrescu RL, Cooper CE, Rinaldo S, Cutruzzola F, Wilson MT, Reaction of Aplysia limacina metmyoglobin with hydrogen peroxide, Dalton Trans, 2007.

* Schwartz, Jennifer K.; Liu XF; Albetel AN; Silaghi-Dumitrescu, Radu, Kurtz, Donald M, Jr.; Theil, Elizabeth C; Solomon, Edward I, Structure/function correlations in binuclear non-heme ferrous sites: Specific characterization of the active sites in m-Ferritin and nitric oxide reductases, Abstracts of Papers, 231st ACS National Meeting, United States, March 26, 2006, INOR-89, 2006.

* Silaghi-Dumitrescu, Radu; Silaghi-Dumitrescu, Ioan; Coulter, Eric D.; Kurtz, Donald M., Jr., Computational study of the non-heme iron active site in superoxide reductase and its reaction with superoxide, Inorganic Chemistry, 42(2), 2003.

* Silaghi-Dumitrescu, Radu; Coulter, Eric D.; Das, Amaresh; Ljungdahl, Lars G.; Jameson, Guy N. L.; Huynh, Boi Hanh; Kurtz, Donald M., Jr., A flavodiiron protein and high molecular weight rubredoxin from Moorella thermoacetica with nitric oxide reductase activity, Biochemistry, 42(10), 2003.

* Silaghi-Dumitrescu, Radu, Nitric oxide reduction by heme-thiolate enzymes (P450nor): A reevaluation of the mechanism, European Journal of Inorganic Chemistry, 2003.

* Kurtz, Donald M., Jr.; Silaghi-Dumitrescu, Radu; Das, Amaresh; Jameson, Guy; Ljungdahl, Lars; Huynh, Boi Hanh, A non-heme iron nitric oxide reductase that protects against nitrosative stress in acetogenic bacteria, Journal of Inorganic Biochemistry, 96, 2003.

* Kurtz, Donald M., Jr.; Emerson, Joseph P; Silaghi-Dumitrescu, Radu; Kung, Irene; Das, Amaresh; Ljungdahl, Lars, How microbes detoxify superoxide, hydrogen peroxide and nitric oxide. The non-heme iron reductive paradigm, Journal of Inorganic Biochemistry, 96, 2003.

* Silaghi-Dumitrescu, Radu; Silaghi-Dumitrescu, Ioan, Hemes revisited by density functional approaches. 1. The axial ligand and the dioxygen-peroxo chemistry, Revue Roumaine de Chimie, 3-4, 2004.

* Silaghi-Dumitrescu, Radu, Heme ferrous-hydroperoxo complexes: some theoretical considerations, Archives of Biochemistry and Biophysics, 424, 2004.

* Silaghi-Dumitrescu, Radu, On the performance of the PM3 semiempirical method with heme complexes relevant to dioxygen and peroxide activation, Revista de Chimie, 55, 2004.

* Silaghi-Dumitrescu, Radu, The nitric oxide adducts of cytochrome cd1 nitrite reductase, Revista de Chimie, 55, 2004.

* Silaghi-Dumitrescu, Radu, The nature of the “high-valent” complexes in the catalytic cycles of hemoproteins, Journal of Biological Inorganic Chemistry, 9, 2004.

* Silaghi-Dumitrescu, Radu, Linkage isomerism in nitrite reduction by cytochrome cd1 nitrite reductase, Inorganic Chemistry, 43(12), 2004.

* Kurtz, Donald M.; Lanzilotta, William N.; Silaghi-Dumitrescu, Radu, How microbes detoxify superoxide, hydrogen peroxide, and nitric oxide: The non-heme iron reductive paradigm, Abstracts of Papers, 227th ACS National Meeting, Anaheim, CA, United States, March 28-April 1, 2004, 2004.

* Das, Amaresh; Silaghi-Dumitrescu, Radu; Ljungdahl, Lars G.; Kurtz, Donald M., Jr., Cytochrome bd oxidase, oxidative stress and dioxygen tolerance of the strictly anaerobic bacterium, Moorella thermoacetica, Journal of Bacteriology, 187(6), 2005.

* Silaghi-Dumitrescu, Radu; Ng, Kim Yong; Viswanathan, Rathinam, Kurtz, Donald M. Jr., A Flavo-diiron protein from Desulfovibrio vulgaris with oxidase and nitric oxide reductase activities. Evidence for an In vivo nitric oxide scavenging function, Biochemistry, 44(9), 2005.

* Silaghi-Dumitrescu, Radu, Nitrile hydration by the cobalt-containing nitrile hydratase. DFT investigation of the mechanism, Revista de Chimie, 56(4), 2005.

* Silaghi-Dumitrescu, Radu, A density functional study of heme-peroxynitrite adducts, Journal of Molecular Structure THEOCHEM, 722, 2005.

* Silaghi-Dumitrescu, Radu, Kurtz, Donald M. Jr., Ljungdahl, Lars G., Lanzilotta, William N, X-ray Crystal Structures of Moorella thermoacetica FprA. Novel Diiron Site Structure and Mechanistic Insights into a Scavenging Nitric OxideReductase, Biochemistry, 44(17), 2005.

* Iyer, Ramesh,* Silaghi-Dumitrescu, Radu,* Lanzilotta, William N. Kurtz, Donald M. Jr., High-resolution crystal structures of Desulfovibrio vulgaris (Hildenborough) nigerythrin: facile, redox-dependent iron movement, domain interface variability, and peroxidase activity in the rubrerythrins, Journal of Biological Inorganic Chemistry, 10, 2005.

* Iyer, Ramesh B.; Silaghi-Dumitrescu, Radu; Lanzilotta, William N.; Kurtz, Donald M, Novel non-heme diiron bacterial peroxidases, Abstracts of Papers, 229th ACS National Meeting, San Diego, CA, United States, March 13-17, 2005, 2005.

* Silaghi-Dumitrescu, Radu; Cooper, Chris E, Transient species involved in catalytic dioxygen/peroxide activation by hemoproteins: possible involvement of protonated compound I species, Dalton Transactions, 2005.

* Silaghi-Dumitrescu, Radu; Silaghi-Dumitrescu, Ioan, DFT and the electromerism in complexes of iron with diatomic ligands, Journal of Inorganic Biochemistry, 100(1), 2006.

* Silaghi-Dumitrescu, Radu, Copper-containing nitrite reductase: a DFT study of nitrite and nitric oxide adducts, Journal of Inorganic Biochemistry, 100(3), 2006.

* Dunne, Jacqueline; Caron, Alexis; Menu, Patrick; Alayash, Abdu I.; Buehler, Paul W.; Wilson, Michael T.; Silaghi-Dumitrescu, Radu; Faivre, Beatrice; Cooper, Chris E, Ascorbate removes key precursors to oxidative damage by cell free hemoglobin in vitro and in vivo, Biochemical Journal, 399(3), 2006.

* Isaza, Clara E.; Silaghi-Dumitrescu, Radu; Iyer, Ramesh B.; Kurtz, Donald M. Jr.; Chan, Michael K, Structural Basis for O2 Sensing by the Hemerythrin-like Domain of a Bacterial Chemotaxis Protein: Substrate Tunnel and Fluxional N Terminus, Biochemistry, 45(30), 2006.