Radu Daniel Rudic

In the cardiovascular system, there are known 24-hour rhythms in blood pressure, heart rate, and blood vessel contractility--circadian rhythms.Ground-breaking work in mice has uncovered the molecular basis of circadian rhythms in behavioral function. However it remains unknown how and if these signals contribute to the rhythms in cardiovascular function. Moreover, if an 'exploding clock' might contribute to the evolution of human disease is unknown. Using in vitro and in vivo models, we seek to examine the role of the circadian clock in normal and pathophysiologic cardiovascular function.

Medical College of Georgia, Augusta, .

E-mail: trimite un mesaj.

Pagina web a instituţiei: http://www.mcg.edu/SOM/phmtox/phtx_faculty_rudic.html
Pagina web personala: http://www.mcg.edu/SOM/phmtox/RudicLab/index.asp

Nascut(a) in: 1968

Interese: ritmul circadian, biologia vasculara, refacerea [remodelarea] cardio vasculara

Detalii:
Ritmul circadian in sistemul cardio vascular,
este o cadenta de 24 de ore in tensiunea arteriala, bataile inimii si contractilitatea vasculara.

Observatii stiintifice seminale au facilitat descoperirea de mecanisme care ar putea explica initierea ritmului circadian in repaus si activitate, dar inca nu se cunoaste daca mecanismul circadian contribuie la ritmul cardiovascular sau abnormalitati ale sistemului circadian pot facilita, provoca evolutia bolii.

Laboratorul nostru se ocupa in prezent de examinarea pe animale [soreci], prin metode moleculare, a ritmului circadian si rolului sau in fiziologia si patologia cardiovasculara.

Details:
In the cardiovascular system, there are known 24-hour rhythms in blood pressure, heart rate, and blood vessel contractility--circadian rhythms.

Ground-breaking work in mice has uncovered the molecular basis of circadian rhythms in behavioral function. However it remains unknown how and if these signals contribute to the rhythms in cardiovascular function. Moreover, if an 'exploding clock' might contribute to the evolution of human disease is unknown. Using in vitro and in vivo models, we seek to examine the role of the circadian clock in normal and pathophysiologic cardiovascular function.

Publicații selectate:

* Papapetropoulos A, Desai KM, Rudic RD, Mayer B, Zhang R, Ruiz-Torres MP, Garcia-Cardena G, Madri JA, Sessa WC, Nitric oxide synthase inhibitors attenuate transforming-growth-factor-beta 1-stimulated capillary organization in vitro, Am J Pathol, 150, 1997.

* Rudic RD, Shesely EG, Maeda N, Smithies O, Segal SS, Sessa WC, Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling, J Clin Invest, 101, 1998.

* Rudic RD, Sessa WC, Nitric oxide in endothelial dysfunction and vascular remodeling: clinical correlates and experimental links, Am J Hum Genet, 64, 1999.

* Papapetropoulos A, Rudic RD, Sessa WC, Molecular control of nitric oxide synthases in the cardiovascular system, Cardiovasc Res, 43, 1999.

* Rudic RD, Bucci M, Fulton D, Segal SS, Sessa WC, Temporal events underlying arterial remodeling after chronic flow reduction in mice: correlation of structural changes with a deficit in basal nitric oxide synthesis, Circ Res, 86, 2000.

* Luo Z, Fujio Y, Kureishi Y, Rudic RD, Daumerie G, Fulton D, Sessa WC, Walsh K, Acute modulation of endothelial Akt/PKB activity alters nitric oxide-dependent vasomotor activity in vivo, J Clin Invest, 106, 2000.

* Bucci M, Gratton JP, Rudic RD, Acevedo L, Roviezzo F, Cirino G, Sessa WC, In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation, Nat Med, 6, 2000.

* Tereb DA, Kirkiles-Smith NC, Kim RW, Wang Y, Rudic RD, Schechner JS, Lorber MI, Bothwell AL, Pober JS, Tellides G, Human T cells infiltrate and injure pig coronary artery grafts with activated but not quiescent endothelium in immunodeficient mouse hosts, Transplantation, 71, 2001.

* McNamara P, Seo SP, Rudic RD, Sehgal A, Chakravarti D, FitzGerald GA, Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock, Cell, 105, 2001.

* Scotland RS, Morales-Ruiz M, Chen Y, Yu J, Rudic RD, Fulton D, Gratton JP, Sessa WC, Functional reconstitution of endothelial nitric oxide synthase reveals the importance of serine 1179 in endothelium-dependent vasomotion, Circ Res, 90, 2002.

* Yu J, Rudic RD, Sessa WC, Nitric oxide-releasing aspirin decreases vascular injury by reducing inflammation and promoting apoptosis, Lab Invest, 82, 2002.

* Curtis AM, Seo SB, Westgate EJ, Rudic RD, Smyth EM, Chakravarti D, FitzGerald GA, McNamara P, Histone acetyltransferase-dependent chromatin remodeling and the vascular clock, J Biol Chem, 279, 2004.

* Sato TK, Panda S, Miraglia LJ, Reyes TM, Rudic RD, McNamara P, Naik KA, FitzGerald GA, Kay SA, Hogenesch JB., A functional genomics strategy reveals Rora as a component of the mammalian circadian clock, Neuron, 43, 2004.

* Rudic RD, McNamara P, Curtis AM, Boston RC, Panda S, Hogenesch JB, Fitzgerald GA., BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis, PLoS Biol, 11, 2004.

* Rudic RD, Curtis AM, Cheng Y, Fitzgerald G., Peripheral clocks and the regulation of cardiovascular and metabolic function, Methods Enzymol, 393, 2005.

* Rudic RD, Brinster D, Cheng Y, Fries S, Song WL, Austin S, Coffman TM, FitzGerald GA., COX-2-derived prostacyclin modulates vascular remodeling, Circ Res, 96., 2005.

* Rudic RD, McNamara P, Reilly D, Grosser T, Curtis AM, Price TS, Panda S, Hogenesch JB, FitzGerald GA., Bioinformatic analysis of circadian gene oscillation in mouse aorta, Circulation, 112, 2005.