Adrian C Apetri

YALE University/Howard Hughes Medical Institute, New Haven, .

E-mail: trimite un mesaj.

Pagina web a instituţiei: http://www.hhmi.org
Pagina web personala: http://www.yale.edu

Nascut(a) in: 1973

Interese: biophysics, protein chemistry, protein misfolding, prion diseases, amyloids, spectroscopy, chaperones

Details:
Folding and Misfolding of Human Prion protein followed by ultrafast mixing methods;
Mechanism of prion fibril formation;
Effect of Chaperones on the folding pathway of proteins associated with neurodegenerative diseases;

Publicații selectate:

* Apetri, Adrian C. and Horwich, Arthur L, Chaperonin chamber accelerates protein folding through passive action of preventing aggregation, National Academy of Sciences - USA, PNAS, 2008.

* Cobb Nathan J, Apetri Adrian C, Surewicz Witold K., Prion protein amyloid formation under native-like conditions involves refolding of the c-terminal alpha -helical domain, The American Society for Biochemistry and Molecular Biology, Journal of Biological Chemistry, 2008.

* Apetri AC, Surewicz WK., Kinetic intermediate in the folding of human prion protein, Journal of Biological Chemistry, 277(47), 2002.

* Apetri AC, Surewicz WK, Atypical effect of salts on the thermodynamic stability of human prion protein, Journal of Biological chemistry, 278(25), 2003.

* Apetri AC, Surewicz K, Surewicz WK., The effect of disease-associated mutations on the folding pathway of human prion protein, Journal of Biological Chemistry, 279(17), 2004.

* Apetri AC, Vanik DL, Surewicz WK., Polymorphism at residue 129 modulates the conformational conversion of the D178N variant of human prion protein 90-231, American Chemical Society, Biochemistry, 44(48), 2005.

* Surewicz WK, Jones EM, Apetri AC., The emerging principles of mammalian prion propagation and transmissibility barriers: Insight from studies in vitro, American Chemical Society, Acc Chem Res. (review), 39(9), 2006.

* Apetri AC, Maki K, Roder H, Surewicz WK, Early intermediate in human prion protein folding as evidenced by ultrarapid mixing experiments, J Am Chem Soc, 128(35), 2006.