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Tudor Oprea

Tudor Oprea

* Bacalaureat, chimie industriala, 1983, Timisoara
* Doctor-medic, medicina generala, 1990, Timisoara
* Doctor in stiinte medicale, 1992, Timisoara (cu Francisc Schneider)
* Visiting Scientist, Univ Utrecht (Olanda), 1990-1991
* Post-doc, Washington University St. Louis, 1992-1994 (cu Garland Marshall)
* Post-doc, Los Alamos National Laboratory, 1994-1996 (cu Angel Garcia)
* Research Scientist (1996-2000), apoi Associate Director, Enabling Science and Technologies (2000-2002), AstraZeneca R&D, Suedia
* Profesor, Univ Vest Timisoara (1999-2003), part-time
* Profesor, Univ of New Mexico, Dept of Biochemistry and Molecular Biology, 2002-2012 (Chief, Division of Biocomputing)
* Profesor, Univ of New Mexico, Dept of Internal Medicine, 2012-prezent (Chief, Translational Informatics Division)

* detalii suplimentare:
* profil Google Scholar:
* profil LinkedIn:

University of New Mexico School of Medicine, Albuquerque, New Mexico, .

E-mail: trimite un mesaj.

Pagina web a instituţiei:
Pagina web personala:

Urmareste linkul ResearcherID pentru toate articolele cercetatorului: A-5746-2011. Tabelul detaliat al articolelor este in josul paginii.

Nascut(a) in: 1965

Interese: Informatica, Modelare Moleculara, QSAR, Descoperirea Medicamentelor, Machine Learning, Health Informatics

flag Detalii:
Interesat in descoperirea medicamentelor, folosind informatica medicala, chimica si bioinformatica. Expert in informatica medicamentului, reprofilare de medicamente, si screening virtual. In prezent lucrez la prioritizarea de tinte pentru medicamente ( Vezi si versiunea in limba engleza.

flag Details:
Health informatics scientist with interests in knowledge management applied to lead and drug discovery, target and drug repurposing, translational informatics and health-record analytics. I contributed to conceptual developments for lead-likeness, systems chemical biology, and the identification of selective, potent compounds for the G-protein estrogen receptor, the formyl peptide receptors FPR1 and FPR2, the Rac1 and Cdc42 GTP-ases, and GLUT5, a fructose-only transporter. My work led to clinical trials for Raltegravir and Ketorolac, both evaluated as anti-cancer agents. I serve as PI for the NIH project "Illuminating the Druggable Genome Knowledge Management Center“ (see also

Publicații selectate:

* T.I. Oprea, Lead structure searching: Are we looking at the appropriate property?, J. Comput.-Aided Mol. Design, 16, 2002.

* L. Kurunczi, M. Olah, T.I. Oprea, C. Bologa, Z. Simon, MTD-PLS: A PLS-Based Variant of the MTD Method. 2. Mapping Ligand-Receptor Interactions. Enzymatic Acetic Acid Esters Hydrolysis, Journal of Chemical Information and Computer Science, 42, 2002.

* Tudor I Oprea, Chemical space navigation in lead discovery, Current Opinion in Chemical Biology, 6, 2002.

* Zamora, Ismael; Oprea, Tudor I.; Ungell, Anna-Lena, Prediction of oral drug permeability, Prous Science, Barcelona, Spain, Hoeltje, Hans-Dieter; Sippl, Wolfgang, Rational Approaches to Drug Design, Proceedings of the 13th European Symposium on Quantitative Structure-Activity Relationships, 2001.

* Oprea, Tudor I.; Gottfries, Johan, ChemGPS: A chemical space navigation tool, Prous Science, Barcelona, Spain, Hoeltje, Hans-Dieter; Sippl, Wolfgang, Rational Approaches to Drug Design, Proceedings of the 13th European Symposium on Quantitative Structure-Activity Relationships, 2001.

* Oprea, Tudor I.; Zamora, Ismael; Ungell, Anna-Lena, Pharmacokinetically Based Mapping Device for Chemical Space Navigation, Journal of Combinatorial Chemistry, 4, 2002.

* Head, Richard D.; Smythe, Mark L.; Oprea, Tudor I.; Waller, Chris L.; Green, Stuart M.; Marshall, Garland R, VALIDATE: A New Method for the Receptor-Based Prediction of Binding Affinities of Novel Ligands., J. Am. Chem. Soc., 118(16), 1996.

* Oprea, Tudor I.; Garcia, Angel E., Three-dimensional quantitative structure-activity relationships of steroid aromatase inhibitors., J. Comput.-Aided Mol. Des., 10(3), 1996.

* Oprea, Tudor Ionel; Kurunczi, Ludovic; Timofei, Simona, QSAR studies of disperse azo dyes. Towards the negation of the pharmacophore theory of dye-fiber interaction?, Dyes Pigm., 33(1), 1997.

* Waller, Chris L.; Oprea, Tudor I.; Chae, Kun; Park, Hee-Kyoung; Korach, Kenneth S.; Laws, Susan C.; Wiese, Thomas E.; Kelce, William R.; Gray, L. Earl Jr, Ligand-Based Identification of Environmental Estrogens., Chem. Res. Toxicol., 9(8), 1996.

* Tung, C.-S.; Oprea, T. I.; Hummer, G.; Garcia, A. E., Three-dimensional model of a selective theophylline-binding RNA molecule., J. Mol. Recognit., 9(4), 1996.

* Sulea, Traian; Oprea, Tudor Ionel; Muresan, Sorel; Chan, Shek Ling, A different method for steric field evaluation in CoMFA improves model robustness., J. Chem. Inf. Comput. Sci., 37(6), 1997.

* Oprea, Tudor I.; Marshall, Garland R, Receptor-based prediction of binding affinities., Perspect. Drug Discovery Des., 9-11, 1998.

* Oprea, Tudor I., Virtual Screening in Lead Discovery: A Viewpoint, Molecules, 7(1), 2002.

* Sulea, Traian; Kurunczi, Ludovic; Oprea, Tudor I.; Simon, Zeno., MTD-ADJ: a multiconformational minimal topologic difference for determining bioactive conformers using adjusted biological activities., J. Comput.-Aided Mol. Des., 12(2), 1998.

* Oprea, Tudor I.; Hummer, Gerhard; Garcia, Angel E., Identification of a functional water channel in cytochrome P450 enzymes., Proc. Natl. Acad. Sci. U. S. A., 94(6), 1997.

* Teague, Simon J.; Davis, Andrew M.; Leeson, Paul D.; Oprea, Tudor I., The design of leadlike combinatorial libraries., Angew. Chem., Int. Ed., 38(24), 1999.

* Oprea, Tudor I., Property distribution of drug-related chemical databases., J. Comput.-Aided Mol. Des., 14(3), 2000.

* Oprea, T. I.; Gottfries, J., Toward minimalistic modeling of oral drug absorption., Journal of Molecular Graphics & Modelling, 17(5/6), 1999.

* Oprea, T. I.; Gottfries, J.; Sherbukhin, V.; Svensson, P.; Kuhler, T. C., Chemical information management in drug discovery: optimizing the computational and combinatorial chemistry interfaces., J. Mol. Graphics Modell., 18(4/5), 2000.

* Oprea, Tudor I.; Gottfries, Johan., Chemography: The Art of Navigating in Chemical Space., Journal of Combinatorial Chemistry, 3(2), 2001.

* Olsson, Thomas; Oprea, Tudor I., Cheminformatics: a tool for decision-makers in drug discovery., Curr. Opin. Drug Discovery Dev., 4(3), 2001.

* Oprea, Tudor I.; Davis, Andrew M.; Teague, Simon J.; Leeson, Paul D., Is There a Difference between Leads and Drugs? A Historical Perspective., Journal of Chemical Information and Computer Sciences, 41(5), 2001.

* Nilsson, Jonas W.; Thorstensson, Fredrik; Kvarnstroem, Ingemar; Oprea, Tudor I.; Samuelsson, Bertil; Nilsson, Ingemar., Solid-phase synthesis of libraries generated from a 4-phenyl-2-carboxy-piperazine scaffold., Journal of Combinatorial Chemistry, 3(6), 2001.

* Oprea, Tudor I.; Kurunczi, Ludovic; Olah, Marius; Simon, Zeno, MTD-PLS: a PLS-based variant of the MTD method. A 3D-QSAR analysis of receptor affinities for a series of halogenated dibenzoxin and biphenyl derivatives., SAR QSAR Environ. Res., 12(1-2), 2001.

* Oprea, Tudor I., Rapid estimation of hydrophobicity for virtual combinatorial library analysis., SAR and QSAR in Environmental Research, 12(1-2), 2001.

* Mracec, Maria; Oprea, Tudor I.; Mracec, Mircea, Correlation between experimental electron affinities for aromatic derivatives and the values calculated with semiempirical MO methods., Revue Roumaine de Chimie, 45(10), 2000.