Alexandru Babes

Universitatea Bucuresti, Bucuresti, .

E-mail: trimite un mesaj.

Pagina web a instituţiei: http://biologie.kappa.ro
Pagina web personala: http://biologie.kappa.ro

Urmareste linkul ResearcherID pentru toate articolele cercetatorului: A-6212-2010. Tabelul detaliat al articolelor este in josul paginii.

Nascut(a) in: 1971

Interese: durere, neurostiinte, canale ionice, frig, inflamatie

Detalii:
Activitatea de cercetare in laboratorul meu este directionata catre intelegerea mecanismelor periferice implicate in noiceptie si traducerea stimulilor termici. Folosind metode electrofiziologice si imagistica de calciu investigam o serie de canale ionice si receptori exprimati la nivelul terminatiilor nervoase, precum TRPV1, TRPV2, TRPM8 si TRPA1.

Publicații selectate:

* Ciobanu AC, Selescu T, Gasler I, Soltuzu L, Babes A., Glycolytic metabolite methylglyoxal inhibits cold and menthol activation of the transient receptor potential melastatin type 8 channel., J Neurosci Res, 94(3), 2016.

* Khalil M, Babes A, Lakra R, Försch S, Reeh PW, Wirtz S, Becker C, Neurath MF, Engel MA., Transient receptor potential melastatin 8 ion channel in macrophages modulates colitis through a balance-shift in TNF-alpha and interleukin-10 production., Mucosal Immunol.

* Bierhaus A, Fleming T, Stoyanov S, Leffler A, Babes A, Neacsu C, Sauer SK, Eberhardt M, Schnölzer M, Lasischka F, Neuhuber WL, Kichko TI, Konrade I, Elvert R, Mier W, Pirags V, Lukic IK, Morcos M, Dehmer T, Rabbani N, Thornalley PJ, Edelstein D, Nau C, Fo, Methylglyoxal modification of Na(v)1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy, Nature Medicine, 2012.

* Engel, MA; Leffler, A; Niedermirtl, F; Babes, A; Zimmermann, K; Filipovic, MR; Izydorczyk, I; Eberhardt, M; Kichko, TI; Mueller-Tribbensee, SM; Khalil, M; Siklosi, N; Nau, C; Ivanovic-Burmazovic, I; Neuhuber, WL; Becker, C; Neurath, MF; Reeh, PW, TRPA1 and Substance P Mediate Colitis in Mice, Gastroenterology, 141(4), 2011.

* Neacsu C, Ciobanu C, Barbu I, Toader O, Szegli G, Kerek F, Babes A., Substance MCS-18 isolated from Helleborus purpurascens is a potent antagonist of the capsaicin receptor, TRPV1, in rat cultured sensory neurons., Physiol Res., 59(2), 2010.

* Neacsu C, Babes A., The M-channel blocker linopirdine is an agonist of the capsaicin receptor TRPV1, J Pharmacol Sci., 114(3), 2010.

* Babes A, Fischer MJ, Reid G, Sauer SK, Zimmermann K, Reeh PW, Electrophysiological and neurochemical techniques to investigate sensory neurons in analgesia research, Springer, Methods in Molecular Biology, 617, 2010.

* Ciobanu C, Reid G, Babes A, Acute and chronic effects of neurotrophic factors BDNF and GDNF on responses mediated by thermo-sensitive TRP channels in cultured rat dorsal root ganglion neurons, Elsevier, Brain Research, 1284, 2009.

* Leffler A, Linte RM, Nau C, Reeh P, Babes A, A high-threshold heat-activated channel in cultured rat dorsal root ganglion neurons resembles TRPV2 and is blocked by gadolinium, European Journal of Neuroscience, 26(1), 2007.

* Linte, R.M., Ciobanu, C., Reid, G., Babes, A, Desensitization of cold- and menthol-sensitive rat dorsal root ganglion neurones by inflammatory mediators, Experimental Brain Research, 178, 2007.

* Zimmermann, K., Leffler, A., Babes, A., Cendan, C. M., Carr, R. W., Kobayashi, J., Nau, C., Wood, J. N., Reeh, P, Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures, Nature, 447, 2007.