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Gertrude-Emilia Costin

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Institute for In Vitro Sciences, Gaithersburg, .

E-mail: trimite un mesaj.

Pagina web a instituţiei: http://www.iivs.org

Nascut(a) in: 1974

Interese: pigmentation

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background in glycobiology, cell and molecular biology, pigmentation, cosmetic industry, toxicology

Publicații selectate:

* Birlea, S. A.; Costin, G.-E.; Norris, D. A., Cellular and Molecular Mechanisms Involved in the Action of Vitamin D Analogs Targeting Vitiligo Depigmentation, Current Drug Targets, 9 (4), 2008.

* Costin, G.-E., Fatu, C.,, Molecular mechanisms and therapeutics concerning acquired immunodeficiency syndrome, Stud. And Res. Of Biochim.,, 41 (1-2), 1998.

* Costin, G.-E., Fatu, C., Bostangiu, M., Tumoral markers in cancer, Stud. And Res. Of Biochim., 41 (1-2), 1998.

* Negroiu, G., Branza-Nichita, N., Costin, G.-E., Titu, H., Petrescu, A.-J., Dwek, R. A., Petrescu, S. M., Investigation of the intracellular transport of tyrosinase and tyrosinase related protein (TRP-1). The effect of endoplasmic reticulum (ER)-glucosidases inhibition, Cell. Mol. Biol (Melanocytes and Melanogenesis), 45 (7), 1999.

* Costin, G.-E., Petrescu S. M., Inhibitors of N-linked glycoproteins biosynthesis and processing, Rom. J. Biochem., 38 (2), 2001.

* Toyofuku, K., Valencia, J. C., Kushimoto, T., Costin, G.-E., Virador, V. M., Vieira, W. D., Ferrans, V. J., Hearing, V. J., The etiology of oculocutaneous albinism (OCA) type II: the pink protein modulates the processing and transport of tyrosinase, Pigment Cell Res., 15 (3), 217-224, 2002.

* Costin, G.-E., Trif, M., Nichita, N., Dwek, R. A., Petrescu, S. M., pH-sensitive liposomes are efficient carriers for endoplasmic reticulum targeted drugs in mouse melanoma cells, BBRC, 293 (3), 2002.

* Kushimoto, T., Valencia, J. C., Costin, G.-E., Toyofuku, K., Watabe, H., Yasumoto, K.-I., Rouzaud, F., Vieira, W. D., Hearing, V. J., “Makoto Seiji memorial lecture”: The melanosome: an ideal model to study cellular differentiation” (review), Pigment Cell Res. (Proceedings of the XVIIIth International Pigment Cell Conference (IPCC)), 16 (3), 2003.

* Costin, G.-E., Valencia, J. C., Vieira, W. D., Lamoreux, M. L., Hearing, V. J., Tyrosinase processing and intracellular trafficking is disrupted in mouse primary melanocytes carrying the underwhite (uw) mutation. A model for oculocutaneous albinism (OCA) Type 4, J. Cell. Sci., 116 (15), 2003.

* Rouzaud, F., Annereau, J.-P., Valencia, J. C., Costin, G.-E., Hearing, V. J., Regulation of melanocortin 1 receptor expression at the mRNA and protein levels by its natural agonist and antagonist, FASEB J., 17 (14), 2003.

* Costin, G.-E., What is the advantage of having melanin in parts of the central nervous system (e.g. substantia nigra)?, IUBMB Life, 56 (1), 2004.

* Costin, G.-E., Vieira, W. D., Valencia, J. C., Rouzaud, F., Lamoreux, M. L., Hearing, V. J., Immortalization of mouse melanocytes carrying mutations in various pigmentation genes, Anal. Biochem., 335 (1), 2004.

* Greggio, E., Bergantino, E., Carter, D., Ahmad, R., Costin G.-E., Hearing, V. J., Clarimon, J., Singleton, A., Eerola, J., Hellström, O., Tienari, P. J., Miller, D. W., Beilina, A., Bubacco, L., Cookson, M. R., Tyrosinase exacerbates dopamine and -synuclein toxicity but is not genetically associated with Parkinson’s disease, J. Neurochem., 93, 2005.

* Gertrude-E. Costin, Julio C. Valencia, Kazumasa Wakamatsu, Shosuke Ito, Wilfred D. Vieira, Yuji Yamaguchi, Adina L. Milac, François Rouzaud, Andrei-J. Petrescu, M. Lynn Lamoreux, Vincent J. Hearing, Mutations in the mouse Dct gene induce a reduction of eumelanin and an increase in the level of pheomelanin produced by melanocytes in culture, Biochem. J., 391 (2), 2005.

* Hideya Ando, Zhi-Ming Wen, Hee-Yong Kim, Norman Salem, Jr., Julio C. Valencia, Gertrude-E. Costin, Hidenori Watabe, Ken-ichi Yasumoto, Yoko Niki, Hirofumi Kondoh, Masamitsu Ichihashi, Vincent J. Hearing, Modulating the intracellular composition of fatty acids affects the post-Golgi degradation of tyrosinase and elicits its retention in the endoplasmic reticulum by hyper-ubiquitination and proteasome inhibition, Biochem. J., 394 (1), 2005.

* Gertrude-E. Costin, Stanca A. Birlea, What is the mechanism for the pigmentation that so commonly accompanies human pregnancy?, IUBMB Life, 58 (1), 2006.

* Stanca Birlea, Marius Birlea, Danut Cimponeriu, Pompilia Apostol, Rodica Cosgarea, Lucian Gavrila, Stefan Tigan, Gertrude Costin, Pranab K. Das, Autoimmune diseases and vitamin D receptor Apa-I polymorphism are associated with vitiligo in a small inbred Romanian community, Acta Derm. Venereol., 86 (3), 2006.

* F. Rouzaud, G-E. Costin, Y. Yamaguchi, J. C. Valencia, W. F. Berens, K. G. Chen, T. Hoashi, M. Bohm, Z. A. Abdel-Malek, V. J. Hearing, Regulation of constitutive and UVR-induced skin pigmentation by melanocortin 1 receptor isoforms, FASEB J, 20 (11), 2006.

* Costin, GE, Hearing, VJ, . Human skin pigmentation: melanocytes modulate skin color in response to stress., FASEB J, 21(4), 2007.

* Valencia, J. C., Rouzaud, F., Julien, S., Chen, K. G., Passeron, T., Yamaguchi, Y., Abu-Asab, M., Tsokos, M., Costin, G. E., Yamaguchi, H., Miller Jenkins, L. M., Nagashima, K., Appella, E., Hearing, V. J., Sialylated core 1 O-glycans influence the sorting of Pmel17/gp100 and determine its capacity to form fibrils., J. Biol. Chem., 258(5), 2007.