Bogdan O. Popescu

"Victor Babes" National Institute of Pathology, "Carol Davila" University of Medicine and Pharmacy Bucharest, University Hospital Bucharest, Bucharest, .

E-mail: trimite un mesaj.

Nascut(a) in: 1971

Interese: neurostiinte, neurologie, neurodegenerare, apoptoza, semnalizare intracelulara

Detalii:
Sunt interesat in principal de mecanismele patogenice ale bolii Alzheimer si ale bolilor neurodegenerative in general. Activitatea mea de cercetare exploreaza mai ales apoptoza neuronala, rolurile si reglarea presenilinei/gama secretazei si alterarile barierei hematoencefalice in procesele neurodegenerative.

Details:
I am interested in Alzheimer's disease and neurodegenerative diseases pathogenic mechanisms. My research mainly deals with neuronal apoptosis, presenilin/gamma secretase roles and regulation and blood-brain barrier alterations in neurodegeneration.

Publicații selectate:

* Cowburn RF, Popescu BO, Ankarcrona M, Dehvari N, Cedazo-Minguez A, Presenilin-mediated signal transduction, Physiol Behav., 92, 2007.

* Hansson CA, Popescu BO, Laudon H, Cedazo-Minguez A, Popescu LM, Winblad B, Ankarcrona M, Caspase-cleaved presenilin-1 is part of active gamma-secretase complexes, J Neurochem., 97, 2006.

* Popescu BO, Ankarcrona M, Mechanisms of cell death in Alzheimer’s disease: Role of presenilins., J Alzheimers Dis., 6, 2004.

* Popescu BO, Cedazo-Minguez A, Benedikz E, Nishimura T, Winblad B, Ankarcrona M, Cowburn RF, Gamma-secretase activity of presenilin 1 regulates acetylcholine muscarinic receptor mediated signal transduction., J Biol Chem., 279, 2004.

* Cedazo-Mínguez A, Popescu BO, Blanco-Millán JM, Akterin S, Pei JJ, Winblad B, Cowburn RF, Apolipoprotein E and beta-amyloid peptide regulation of glycogen synthase kinase 3-beta., J Neurochem., 87, 2003.

* Popescu BO, Oprica M, Sajin M, Stanciu CL, Bajenaru O, Predescu A, Vidulescu C, Popescu LM, Dantrolene protects neurons against kainic acid induced apoptosis in vitro and in vivo., J Cell Mol Med., 6, 2002.

* Popescu AT, Vidulescu C, Stanciu CL, Popescu BO, Popescu LM, Selective protection by phosphatidic acid against staurosporine-induced neuronal apoptosis, J Cell Mol Med., 6, 2002.

* Cedazo-Minguez A, Popescu BO, Ankarcrona M, Nishimura T, Cowburn RF, The presenilin 1 exon 9 deletion gives enhanced basal phospholipase C activity and a resultant increase in intracellular calcium concentrations., J Biol Chem., 277, 2002.

* Popescu BO, Cedazo-Minguez A, Popescu LM, Winblad B, Cowburn RF, Ankarcrona M., Caspase cleavage of exon 9 deleted presenilin-1 is an early event in apoptosis induced by calcium ionophore A 23187 in SH-SY5Y neuroblastoma cells., J Neurosci Res, 66, 2001.

* Popescu BO, Ankarcrona M, Neurons bearing presenilins: weapons for defense or suicide?, J Cell Mol Med., 4, 2000.

* Zagrean L, Moldovan M, Munteanu AM, Spulber S, Voiculescu BA, Popescu BO., Early electrocortical changes consistent with ischemic preconditioning in rat., J Cell Mol Med., 4, 2000.