Constantin Uglea

Universitatea de Medicina si Farmacie,, Iasi, .

E-mail: trimite un mesaj.

Nascut(a) in: 1945

Interese: recunoastere moleculara,nanotehnologie

Detalii:
Sunt implicat in mai multe programe de cercetare avand ca obiective sinteza si caracterizarea (chimica si preclinica) a unei serii de conjugate polimer-medicament cu activitate antitumorala

Details:
I am involved in a research programm concerning the synrhesis and characterization (chemical and preclinical) of a series of polymer-drug conjugates with antitumoral activity

Publicații selectate:

* V.Sunel,M.Popa,A.D.Stoican,A.A.Popa,C.V.Uglea, Poly(maleic anhydride-alt-vinyl acetate) conjugate with alkylating afents.I. Synthesis and physico-chemical characterization, Materiale Plastice, 45, 2008.

* T.Buruiana, D.Spridon, E.Buruiana, V.Hefco,C.V.Uglea, Polyurethane based on dihydroxamic acids, J.Biomat.Sci.,Polymer Ed.,, 12, 2000.

* Constantin V. Uglea,L.Panaitescu,D. Spridon,D.Ursu, I.Popa,R.M.Ottenbrite, Biological activity of maleic anhydride copolymers, J.Biomat.Eci.,Polymer Ed.,, 8, 1996.

* C.V.Uglea,H.Offenberg,C.Cascaval, Synthesis and characterization of self-colored poly(ethylene terephthalate), Eur.Polymer Journal, 21, 1985.

* C.V.Uglea, Hemicellulose characterization, Die Makromoleculare Chemie, 175, 1974.

* D.Feldman,C.V.Uglea, V.Nuta,M.Popa, Characterization du poly(chlorure de vinyl), Analusis, 1(1), 1972.

* Iuliana Popa, C. Beldie, Offenberg Harry,Constantin V. Uglea, Benzocaine modified maleic anhydride copolymers.I. poly(maleic anhydride-co-vinyl acetate), poly(maleic anhydride-co-methyl methacrylate) and poly(maleic anhydrideco-styrene), Europeean Polymer Journal, 33(9), 1997.

* Constantin V. Uglea, A. Vatajanu, Offenberg Harry, Alexandru Grecianu, R.M.Ottenbrite,Ioan I.Negulescu, Benzocaine modified maleic anhydride-cyclohexyl-1,3-dioxepin copolymer:preparation and potential medical applications, Polymer, 34, 1993.

* Constantin V. Uglea ,Mariana Croitoru, Transport of amino acids through organic liquid membranes.III. The alkaline ion role, Journal of Membrane Science, 133(1), 1997.

* Constantin V. Uglea ,Cristinel V. Zanoaga, Transport of amino acids through organic liquid membranes.IIAspects of the mechanism, Journal of Membrane Science, 65(1-2), 1992.

* Constantin V.Uglea,Cristinel V. Zanoaga, Transport of amino acids through organic liquid membranes.I p-aminobenzoic acid, Journal of Membrane Science, 47(3), 1989.

* D.Spridon,C.V.Uglea, Biological activity of hydroxamic compounds, Marcel Dekker,Inc.,, Biomaterial and Bioengineering Handbook, 2000.

* C.V.Uglea,Cristina Dumitriu-Medivighi, Medical applications of synthetic oligomers, Marcel Dekker,Inc.,, S. Dumitriu, Polymeric Biomaterials, 1994.

* Constantin Uglea,Ioan Corduneanu,Ioan Negulescu, Characterization of polyesters:thermo-oxidative degradation, Monatschefte fur Chemie, 115(3), 1984.

* C.V.Uglea, Liqui Cromatography of Oligomers, Marcel Dekker Inc.,New York, 1996.

* C.V.Uglea,I.I.Hegulescu, Synthesis and characterization of oligomers, CRC Press,Boca Raton, USA, 1992.

* D.Spridon,L.Panaitescu,D.Ursu, C.V.Uglea,I.Popa,R.M.Ottenbrite, Synthesis and biocompatibility of maleic anhydride(ma) copolymers.I.ma-vinyl acetate, ma-methylmethacrylate and ma-styrene, Polymer International, 43(2), 1997.

* C.Cincu,C.V.Uglea, Dilute solution properties of alternating copolymers from methacrylonitrile and styrene and methacrylonitrile and alphamethylstyrene, Die Makromoleculare Chemie, 177(8), 1976.

* D.Feldman,C.V.Uglea,N.Simionescu , Contribution au fractionnement des copolym'eres.II Copolymeres ternaires acrylonitrule-acetate de vinyle-alphamethylstyrene, Journal of Polymer Science,Part A-1:Polymer Chemistry, 7(2), 1969.

* C.V.Uglea, V. Stan, The characterization of dope deyed poly(ethulene yerephthalate), British Polymer Journal, 14(2), 1982.

* M. Bezdadea, C.V.Uglea, Matrix polymerisation of poly(vinyl acetate), British Polymer Journal, 15(3), 1983.

* C.V.Uglea, A. Mihaesu, Unperturbed dimensions and intrinsic viscosity-molecular weight relationship of copolyesters poly(ethylene terephthalate-co-ethylene isophthalate), Journal of Chemical Technology&Biotechnology Chemical Technology, 35(1), 1985.

* C.V.Uglea, I.Albu,A.Vatajanu,M.Croitoru,D.Iurea, M.Isac,R.M.Ottenbrite, Polyanionic Polymers.I.Synthesis, Characterisation, and Potential Medical Applications of Benzocaine Modified Carboxymethylcellulose, Journal Bioactive&Compatible Polymers, 9, 1994.

* C.V.Uglea, I.Albu,A.Vatajanu,M.Croitoru,D.Iurea, M.Isac,R.M.Ottenbrite, Polyanionic Polymers.ISynthesis, Characterisation, and Potential Medical Applications of Benzocaine Modified Carboxymethylcellulose, Journal Bioactive&Compatible Polymers, 9, 1994.

* M. Popa, V. Sunel, N. Dulea, A.A. Popa, R. M. Ottenbrite and C.V.Uglea, Antitumoral Activity Induced by Alkylating Agents Conjugated toPoly(Maleic Anhydride-alt-Vinyl Acetate, Journal of Bioactive &Compatible Polymers, 22(6), 2007.

* Constantin V. Uglea, I. Albu, A. Vatajanu, M. Croitoru, S. Antoniu, L. Panaitescu, R. M. Ottenbrite, Drug Delivery Systems Based on Inorganic Materials:I Synthesis and Characterization of a Zeolite-Cyclophosphamide system, Journal Biomaterial mScience, Polymer Edition, 6(7), 1995.

* Ioan I. Nedulescu and Constantin V. Uglea, Biological Activity of Oxidized Polysaccharides, Kluwer Acad.Publishers, Ed. Edwards and Buschell-Diller, Modified Fibres for Medical and Specialty Applications, 2005.

* C.V.Uglea, A. Parv,M.Corjan, A.D.Dumitriu,R.M.Ottenbrite, Biodistribution and antitumor activity induced by carboxymethylcellulose conjugates, Journal Bioactive and Compatible Polymers,, 20, 2005.