Adina-Luminita Milac

Institute of Biochemistry of the Romanian Academy, Bucharest, .

E-mail: trimite un mesaj.

Pagina web a instituţiei: www.biochim.ro
Pagina web personala: www.biochim.ro

Urmareste linkul ResearcherID pentru toate articolele cercetatorului: C-1070-2011. Tabelul detaliat al articolelor este in josul paginii.

Nascut(a) in: 1974

Interese: biofizica, biochimie structurala, structura, dinamica si functia proteinelor, interactia proteine-liganzi

Details:
I graduated the Faculty of Physics, University of Bucharest, in 1997. I had my masters degree in Biophysics in 1999 and Ph.D. in Physics in 2005 ("Cum Laudae" honors), also at the University of Bucharest.

During my Ph.D. I was a research assistant and then researcher in the Structural Biochemistry Group led by Dr. Andrei J. Petrescu, within the Institute of Biochemistry of the Romanian Academy, Bucharest. This is where I conducted most of my Ph.D. work.

I was a postdoctoral fellow at NIDDK/NIH during July 2005-April 2007, in the group headed by Dr. Lawrence Tabak.

I was a postdoctoral fellow at the Laboratory of Cellular Biology, NCI/NIH, during April 2007-July 2010 in the group headed by. Dr. H. Robert Guy.

I am currently researcher within the Department of Structural Biochemistry and Bioinformatics at the Institute of Biochemistry of the Romanian Academy.
Research area: protein modelling and bioinformatics.

Main results:
- protein 3D structure prediction by homology modeling and analysis of structure-function relationship
- protein dynamics and role of conformational changes in function and substrate binding
- development of a database of structural information on glycoproteins and its use in the comparative analysis of glycoproteins at various structural levels
- protein secondary structure prediction and protein-ligand interaction prediction by neural networks

Publicații selectate:

* Avram S, Berner H, Milac AL, Wolschann P, Quantitative structure - activity relationship studies on membrane receptors inhibition by antipsychotic drugs. Application to schizophrenia treatment, Monatshefte für Chemie / Chemical Monthly, 139(4), 2008.

* Avram S, Buiu C, Borcan F, Milac AL, More effective antimicrobial mastoparan derivatives, generated by 3D-QSAR-Almond and computational mutagenesis, Molecular Biosystems, 8(2), 2012.

* Avram S, Mihailescu D, Borcan F, Milac AL, Prediction of improved antimicrobial mastoparan derivatives by 3D-QSAR-CoMSIA/CoMFA and computational mutagenesis, Monatshefte für Chemie / Chemical Monthly, 143(4), 2012.

* Avram S, Milac AL, Mihailescu D, 3D-QSAR study indicates an enhancing effect of membrane ions on psychiatric drugs targeting serotonin receptor 5-HT1A, Molecular Biosystems, 8(5), 2012.

* Maksaev G, Milac AL, Anishkin A, Guy HR, Sukharev S, Analyses of gating thermodynamics and effects of deletions in the mechanosensitive channel TREK-1: comparisons with structural models, Channel (Austin), 5(1), 2011.

* Milac AL, Anishkin A, Fatakia SN, Chow CC, Sukharev S, Guy HR, Structural models of TREK channels and their gating mechanism, Channels (Austin), 5(1), 2011.

* Avram S, Milac AL, Flonta ML, Computer-Aided Drug Design for Typical and Atypical Antipsychotic Drugs: A Review of Application of QSAR and Combinatorial Chemistry Methods - Tools for New Antipsychotics Design, Current Computer-Aided Drug Design, 1(4), 2005.

* Avram S, Milac AL, Mihailescu DF, Dabu A, Flonta ML, Computer-Aided Drug Design Applied to Beta and Gamma Secretase Inhibitors-Perspectives for New Alzheimer Disease Therapy, Current Enzyme Inhibition, 2(4), 2006.

* Anishkin A, Milac AL, Guy HR, Symmetry-restrained molecular dynamics simulations improve homology models of potassium channels, Proteins: Structure, Function, and Bioinformatics, 2009.

* Petrescu AJ, Milac AL, Petrescu SM, Dwek RA, Wormald MR, Statistical analysis of the protein environment of N-glycosylation sites: implications for occupancy, structure and folding, Glycobiology, 14 (2), 2004.

* Kudla U, Qin L, Milac A, Kielak A, Maissen C, Overmars H, Popeijus H, Roze E, Petrescu A, Smant G, Bakker J, Helder J, Origin, distribution and 3D-modelling of Gr-EXP1, an expansin from the potato cyst nematode Globodera rostochiensis, FEBS Letters, 579, 2005.

* Jaubert S, Milac AL, Petrescu AJ, de Almeida-Engler J, Abad P, and Rosso M-N, In Planta Secretion of a Calreticulin by Migratory and Sedentary Stages of Root-Knot Nematode, Molecular Plant Microbe Interactions, 18(12), 2005.

* Costin GE, Valencia J, Wakamatsu K, Ito S, Solano F, Milac AL, Vieira W, Yamaguchi Y, Rouzaud F, Petrescu AJ, Lamoreux M, Hearing V, Mutations in Dopachrome Tautomerase (Dct) Affect Eumelanin / Pheomelanin Synthesis but do not Affect Intracellular Trafficking of the Mutant Protein, Biochemical Journal, 391(Pt 2), 2005.

* Kudla U, Milac AL, Qin L, Roze E, Holterman M, Petrescu AJ, Goverse A, Bakker J, Helder J, Smant G, Structural and functional characterization of a novel, host penetration-related pectate lyase from the potato cyst nematode Globodera rostochiensiss, Molecular Plant Pathology, 8(3), 2007.

* Milac AL, Avram S, Petrescu AJ, Evaluation of a neural networks QSAR method based on ligand representation using substituent descriptors Application to HIV-1 protease inhibitors, Journal of Molecular Graphics and Modelling, 25, 2005.

* Milac AL, Buchete NV, Fritz TA, Hummer G, Tabak LA, Substrate-induced conformational changes and dynamics of UDP-N-acetylgalactosamine: polypeptide N-acetylgalactosaminyltransferase-2, Journal of Molecular Biology, 373(2), 2007.