Adrian Anghel

UCLA, Los Angeles, .

E-mail: trimite un mesaj.

Pagina web a instituţiei: http://www.ucla.edu
Pagina web personala: http://anghel.exofire.net/

Nascut(a) in: 1966

Interese: Cloning, siRNA, Microarrays, ICAM 1, CaMKII, Opiate Dependency, Pro-protein convertases, Cancer Pathways, Anti-cancer drugs, Clinical and Pre-clinical studies

Details:
MOLECULAR BIOLOGY & GENETICS
- DNA cloning - DNA transfection methods; Vectors derived from plasmids.
- Gene knockout; siRNA transfection;
- Gene expression technology in mammalian cell.
- Mammalian Cell Cultures
- Fluorescences labeling/detection methods.
- DNA Microarrays (Experiments Design and Data Analysis)
- Real-Time Polimerase Chain Reaction (PCR); PCR primers design;
- In vivo: mice, rats; various surgery and behavioral procedures.

PRE-CLINICAL STUDIES AND NEW ANTI-CANCER DRUG DEVELOPEMENT
- pharmacokinetic and pharmacodynamic analysis studies.

Publicații selectate:

* Wainberg ZA, Anghel A, Rogers AM, Desai AJ, Kalous O, Conklin D, Ayala R, O'Brien NA, Quadt C, Akimov M, Slamon DJ, Finn RS., Inhibition of HSP90 with AUY922 induces synergy in HER2-amplified trastuzumab-resistant breast and gastric cancer., Mol Cancer Ther., 12(4), 2013.

* Wang Y, Nakagawa Y, Liu L, Wang W, Ren X, Anghel A, Lutfy K, Friedman TC, Liu Y., Tissue-specific dysregulation of hexose-6-phosphate dehydrogenase and glucose-6-phosphate transporter production in db/db mice as a model of type 2 diabetes., Diabetologia, 54(2), 2011.

* Anghel A, Jamieson CA, Ren X, Young J, Porche R, Ozigbo E, Ghods DE, Lee ML, Liu Y, Lutfy K, Friedman TC, Gene expression profiling following short-term and long-term morphine exposure in mice uncovers genes involved in food intake, Neuroscience, May 5; 167(2), 2010.

* Wainberg ZA, Anghel A, Desai AJ, Ayala R, Luo T, Safran B, Fejzo MS, Hecht JR, Slamon DJ, Finn RS, Lapatinib, a Dual EGFR and HER2 Kinase Inhibitor, Selectively Inhibits HER2-Amplified Human Gastric Cancer Cells and is Synergistic with Trastuzumab In vitro and In vivo, Clin Cancer Res., Mar 1;16(5), 2010.

* Z. A. Wainberg, J. Dering, C. Ginther, A. Anghel, O. Kalous, A. Desai, J. R. Hecht, E. Clark, D. Slamon, R. S. Finn, Identification of predictive markers of response in colorectal cancer following treatment with dasatinib, an orally active tyrosine kinase inhibitor of ABL and SRC, J Clin Oncol, 26, 2008.

* Z.A. Wainberg, A. Desai, B. Safran, A. Anghel, M. Fejzo, J.R. Hecht, D.J. Slamon and R.S. Finn, The EGFR and HER2 dual kinase inhibitor lapatinib selectively inhibits HER2 amplified gastric cancer cells, American Society of Clinical Oncology (ASCO) Gastrointestinal Cancers Symposium, 2009.

* Richard S. Finn, Judy Dering, Delmy Portillo, Amrita Desai, Shariar Adhami, Dylan Conklin, Ondrej Kalous, Adrian Anghel, Greg Bentley, Charles Ginther, Zev Wainberg, Edward Garon, Sauver-Michel Maira, Carlos Garcia-Echeverria, Dennis J. Slamon, Biologic effects of NVP-BEZ235, an orally available dual PI3K/mTOR inhibitor, in human breast, lung, colon, pancreas, and liver cancer cell lines in vitro, AACR 100th Annual Meeting, 2009.

* Zev A. Wainberg, Adrian Anghel, Amrita Desai, Shahriar Adhani, Brent Safran, J Randolph Hecht, Michael Rugard Jensen, Cornelia Quadt, Dennis J. Slamon, Richard S. Finn, Biologic effects of NVP-AUY922, a novel small molecule inhibitor of HSP90 in human colon and gastric cancer cell lines, AACR 100th Annual Meeting, 2009.

* Paez Espinosa V, Liu Y, Ferrini M, Anghel A, Nie Y, Tripathi PV, Porche R, Jansen E, Stuart R, Nillni E, Lutfy K, Friedman TC, Differential regulation of PC1/3, PC2 and phosphorylated CREB by short-term and long-term morphine treatment: Implications for Understanding the “Switch” to Opiate Addiction, Neuroscience, 156(3), 2008.

* Lutfy K, Brown MC, Nerio N, Aimiuwu O, Tran B, Anghel A, Friedman TC, Repeated Stress Alters the Ability of Nicotine to Activate the HPA Axis, Journal of Neurochemistry, 99(5), 2006.

* Liu Y, Yan C, Wang Y, Nakagawa Y, Nerio N, Anghel A, Lutfy K, Friedman TC, Liver X Receptor Agonist T0901317 Inhibition of Glucocorticoid Receptor Expression in Hepatocytes May Contribute to the Amelioration of Diabetic Syndrome in db/db Mice, Endocrinology, 147(11), 2006.