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Marius Mihasan

Marius Mihasan

2004 - 2006 Junior researcher, Albert-Ludwigs-University Freiburg
2006 - 2009 PhD thesis on the role of several genes from the catabolic megaplasmid pAO1 of Arthrobacter nicotinovorans in the lab of Prof. Dr. Roderich Brandsch, Albert-Ludwigs-University, Freiburg and prof. Dr. Vlad Artenie, Alexandru Ioan Cuza University of Iasi
2004 - 2009 Junior researcher at the Institute for Biological Research, Iaşi, Romania
2009 - 2013 Assistant lecturer at the Faculty of Biology, Alexandru Ioan Cuza University of Iasi
2010 - 2012 Postdoc, Laboratory of Molecular and Experimental Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, project PD No. 337
2013 - 2016 Assistant Professor at the Faculty of Biology, Alexandru Ioan Cuza University of Iasi
February – July 2017 Fulbright Research Fellow, Darie Biochemistry & Proteomics Group, Clarkson University, NY, USA
2016 - 2019 Associate professor at the Faculty of Biology, Alexandru Ioan Cuza University of Iasi
Since 2020 Professor, Biochemistry and Molecular Biology Lab, Faculty of Biology, Alexandru Ioan Cuza University

Universitatea Alexandru Ioan Cuza Iasi, Iasi, .

E-mail: trimite un mesaj.

Pagina web a instituţiei:
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Nascut(a) in: 1981

Interese: biologie moleculara, biochimie, proteomics

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The main subject of research is the molecular biology of the pAO1 megaplasmid related to the nicotine-generated oxidative stress defense mechanism as well as sugar-catabolism. I focus on the molecular evolution of the pAO1 megaplasmid as a way of investigating its role in the spreading of catabolic traits among Gram-positive soil bacteria as well as a way of identifying the origin of the megaplasmid. Lately, in collaboration with dr. Lucian Hritcu, I am interested in the evaluation of possible medical applications of the Paenarthrobacter nicotinovorans (former Arthrobacter nicotinovorans) nicotine-derivates. As Paenarthrobacter nicotinovorans could be used to decontaminate nicotine-containing waste, I am also exploring the biotechnological applications of this strain in collaboration with Dr. Stefan Marius.

Most recent selected publications:
Brandsch, R, Mihasan M, A soil bacterial catabolic pathway on the move: Transfer of nicotine catabolic genes between Arthrobacter genus megaplasmids and invasion by mobile elements J Biosci 45, 58 (2020)
Hritcu, L., Mihasan M., 2019. 6-Hydroxy-l-Nicotine and Memory Impairment 6-Hydroxy-l-Nicotine and Memory Impairment, book chapter in Neuroscience of Nicotine Mechanisms and Treatment, Ed. Preedy V, 165-172
Mihasan, M.; Babii, C.; Aslebagh, R.; Channaveerappa, D.; Dupree, E. & Darie, C. C., Proteomics based analysis of the nicotine catabolism in P. nicotinovorans pAO1, Sci Rep 8, 16239 (2018)
Hritcu L, Ionita R, Motei D.E., Babii C., Stefan M., Mihasan M. Nicotine versus 6-Hydroxy-L-Nicotine against Chlorisondamine Induced Memory Impairment and Oxidative Stress in the Rat Hippocampus. Biomed Pharmacother 86, 102–8 (2017)
Mihăşan M, Brandsch R. A predicted T4 secretion system and conserved DNA-repeats identified in a subset of related Arthrobacter plasmids, Microbiol Res 191, 32-37