Mariana Spulber

University of Detroit Mercy, Detroit, .

E-mail: trimite un mesaj.

Nascut(a) in: 1980

Interese: structuri supramoleclare, ESR

Details:
- ESR study of the degradation processes of the perfluorinated membranes and corresponding model compounds for fuel cell design.
- Spin trapping, prolongation of the lifetime and selective encapsulation of spin adducts on cyclodextrins.
- Encapsulations on curcubiturils and intimate characterization of the various inclusion factors by spin probe method.
- Determination of CMC and aggregation behaviour of perfluorinated compounds by spin probing
- AT-IR insight of the degradation of perfluorinated membranes under hydroxyl radicals attack.
Synthesis and purification of polysiloxanes and polysilanes with various functional groups on the main or side chain for various applications and structural characterization by structural studies (NMR, FT-IR) and aggregation ability by fluorescence.
- Polysilanes and polysiloxanes modification by click chemistry for surface engineering.
- Synthesis of fullerene complexes with cyclodextrins and /or copolymers NVP/siloxane in order to increase their solubility in water.
- Determination of the optimal method and conditions for obtaining new complexes of inclusion of hydrophobic antifungal drugs (sulconazole nitrate and 5 flucytosine) with native native cyclodextrins (α, β, γ cyclodextrin), β cyclodextrin derivatives (methyl and hydroxypropyl) and of the conjugates nystatin polymer hydrsoluble (PEO).
- Determination of the minimal inhibitory dose and acute toxicity studies.
-Characterization of the inclusion complexes in native cyclodextrins (α, β, γ cyclodextrin), β cyclodextrin derivatives (methyl and hydroxypropyl) and of the conjugates nystatin polymer hydrsoluble (PEO).
- Determination of the binding constants by Rose Drago and phase solubility method using UV-vis spectroscopy and of the kinetics of reaction
- Correlation between the chemical structure and supramolecular properties, auto-assembling and molecular recognition
- Team member in 15 Romanian and European Projects

Publicații selectate:

* Fifere A, Pinteala M, Spulber M, Harabagiu V, Simionescu BC, Mracec M, Semi-Empirical PM3 Study On The Complexation Of Alpha-Cyclodextrin With 5-Flucytosine. , AIP Conf. Proc., 1148, 2009.

* Spulber M, Pinteala M, Fifere A, Harabagiu V, Simionescu BC, New therapeutically agent with increased antifungal activity, Nova Science Publishers, Macrocyclic Chemistry: New Research Developments, 2010.

* Pricop L, Durdureanu-Agheluta A, Pinteala M, Spulber M, Fifere A, Marangoci N, Dascalu AI, Tigoianu R, Harabagiu V, Simionescu BC, Synthesis and micellization of polydimethylsiloxane-carboxy-terminated poly(ethylene oxide) graft copolymer in aqueous and organic media, E-Polymers, 2010.

* Spulber M, Schlick S, Using Cyclodextrins to Encapsulate Oxygen-Centered and Carbon-Centered Radical Adducts: The Case of DMPO, PBN, and MNP Spin Traps, J. Phys. Chem. A, 114, 2010.

* Schlick S, Spulber M, ESR detection of early events in the fragmentation of perfluorinated model compounds and relevance stability of polymeric membranes used in fuell cells, Mat. Sci. Eng. (PMSE Preprints), 2010.

* Spulber M, Fifere A, Durdureanu-Angheluta A, Fifere N, Nystatin-polyethylene oxide conjugates with enhanced solubility in water, J. Incl. Phenom. Macrocycl. Chem., 2010.