Speranta Avram

Facultatea de Biologie, Bucuresti, .

E-mail: trimite un mesaj.

Nascut(a) in: 1972

Interese: simulare moleculara, HIV/SIDA, QSAR, CoMFA, neurochimie,neurobiologie

Details:
I am a biochemist. In November 2001 I completed my Ph.D with Prof. Dr. Maria-Luiza Flonta, Bucharest University, Faculty of Biology, Department of Physiology and Biophysics, Romania. The subject of my Ph.D Thesis is “THE INTERACTION STUDY OF THE HIV1 PROTEASE AND THEIR INHIBITORS BY MOLECULAR SIMULATION TEHNIQUE”. I have a five years experience in computational chemistry and molecular simulation technique, with emphasis on development of novel HIV-1 protease inhibitors, small molecule modeling (the HIV1 inhibitors and the anesthetics), molecular dynamic study of HIV1 protease mutants, quantitative structure-activity relationships (QSAR) and 3D-QSAR-CoMFA(comparative molecular force field) apply to the HIV-1 protease inhibitors and the local anesthetics, molecular surface and volume calculation for pharmacofore structures and proteins. I have also five years experience in teaching biophysics and molecular modeling to graduate students.During 1997- 1998 I obtained two fellowships in molecular modelling technique at the Computational Chemistry Department, University of Darmstadt Germany (Prof. J. Brickmann), within a TEMPUS Programme
I have a good experience in:
- molecular simulation software running under UNIX (SYBYL, Molcad, CHARMM, Insight, Spartan, GAMESS, Mopac) and under Windows (HyperChem with ChemPlus and HyperNMR, ChemOffice)
- statistical software running under UNIX (e.g., the CoMFA module in SYBYL) and under Windows (Excel, Statistica, Origin)
- semiempirical and Ab initio Quantum Mechanics and Molecular Dynamic
- QSAR (Quantitative structure-activity relationships): Linear and Nonlinear Regression