Otilia Obreja

Universitatea Heidelberg, Mannheim, .

E-mail: trimite un mesaj.

Nascut(a) in: 1970

Interese: neurostiinte, mecanismele durerii cronice, electrofiziologie

Details:
Mechanisms of acute and chronic peripheral sensitization of nociceptors.
Pharmacological modulation of spike initiation site in unmyelinated nociceptors.
HUman and animal models of chronic pain.

Publicații selectate:

* Rukwied R, Mayer A, Kluschina O, Obreja O, Schley M, Schmelz M., GF induces non-inflammatory localized and lasting mechanical and thermal hypersensitivity in human skin., Elsevier, Pain, 2010.

* Linhart O, Obreja O, Kress M., The inflammatory mediators serotonin, prostaglandin E2 and bradykinin evoke calcium influx in rat sensory neurons., Neuroscience, 2003.

* Rathee PK, Distler C, Obreja O, Neuhuber W, Wang GK, Wang SY, Nau C, Kress M., PKA/AKAP/VR-1 module: A common link of Gs-mediated signaling to thermal hyperalgesia., J Neurosci, 2002.

* Distler C, Rathee PK, Lips KS, Obreja O, Neuhuber W, Kress M., Fast Ca2+-induced potentiation of heat-activated ionic currents requires cAMP/PKA signaling and functional AKAP anchoring., J Neurophysiol, 2003.

* Rukwied R, Chizh BA, Lorenz U, Obreja O, Margarit S, Schley M, Schmelz M., Potentiation of nociceptive responses to low pH injections in humans by prostaglandin E2., Elsevier, J Pain, 2007.

* Dusch M, Schley M, Obreja O, Forsch E, Schmelz M, Rukwied R., Comparison of electrically induced flare response patterns in human and pig skin., Inflamm Res, 2009.

* Rukwied R, Schley M, Forsch E, Obreja O, Dusch M, Schmelz M., Nerve growth factor-evoked nociceptor sensitization in pig skin in vivo., J Neurosci Res, 2010.

* Schmidt R, Kleggetveit IP, Namer B, Helås T, Obreja O, Schmelz M, Jørum E., Double spikes to single electrical stimulation correlates to spontaneous activity of nociceptors in painful neuropathy patients., Elsevier, Pain, 2012.

* Weinkauf B, Obreja O, Schmelz M, Rukwied R., Differential effects of lidocaine on nerve growth factor (NGF)-evoked heat- and mechanical hyperalgesia in humans., Elsevier, Eur J Pain, 2012.

* Deising S, Weinkauf B, Blunk J, Obreja O, Schmelz M, Rukwied R., NGF-evoked sensitization of muscle fascia nociceptors in humans., Elsevier, Pain, 2012.

* Obreja O, Schmelz M, Poole S, Kress M., Interleukin-6 in combination with its soluble IL-6 receptor sensitises rat skin nociceptors to heat, in vivo., Elsevier, Pain, 96, 2002.

* Obreja O, Rathee PK, Lips KS, Distler C, Kress M., IL-1 beta potentiates heat-activated currents in rat sensory neurons: involvement of IL-1RI, tyrosine kinase, and protein kinase C., FASEB J, 16, 2002.

* Obreja O, Biasio W, Andratsch M, Lips KS, Rathee PK, Ludwig A, Rose-John S, Kress M., Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons., Brain, 128, 2005.

* Obreja O, Rukwied R, Steinhoff M, Schmelz M., Neurogenic components of trypsin- and thrombin-induced inflammation in rat skin, in vivo., Blackwell Publishing, Exp. Dermatol, 15, 2006.

* Obreja O, Klusch A, Ponelies N, Schmelz M, Petersen M., A subpopulation of capsaicin-sensitive porcine dorsal root ganglion neurons is lacking hyperpolarization-activated cyclic nucleotide-gated channels., Elsevier, Eur J Pain, 12, 2008.

* Obreja O, Schmelz M., Single-fiber recordings of unmyelinated afferents in pig., Neuroscience Letters, 470, 2010.

* Obreja O, Ringkamp M, Namer B, Forsch E, Klusch A, Rukwied R, Petersen M, Schmelz M., Patterns of activity-dependent conduction velocity changes differentiate classes of unmyelinated mechano-insensitive afferents including cold nociceptors, in pig and in human., Elsevier, Pain, 148, 2010.

* Obreja O, Ringkamp M, Turnquist B, Hirth M, Forsch E, Rukwied R, Petersen M, Schmelz M., Nerve growth factor selectively decreases activity-dependent conduction slowing in mechano-insensitive C-nociceptors., Elsevier, Pain, 152, 2011.

* Obreja O, Kluschina O, Mayer A, Hirth M, Schley M, Schmelz M, Rukwied R., NGF enhances electrically induced pain, but not axon reflex sweating., Elsevier, Pain, 152, 2011.

* Obreja O, Hirth M, Turnquist B, Rukwied R, Ringkamp M, Schmelz M., The Differential Effects of Two Sodium Channel Modulators on the Conductive Properties of C-Fibers in Pig Skin In Vivo., Anesthesia Analgesia, 2012.