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Mircea Ivan

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Indiana University Cancer Center, Indianapolis, USA.

E-mail: trimite un mesaj.

Urmareste linkul ResearcherID pentru toate articolele cercetatorului: A-8109-2012. Tabelul detaliat al articolelor este in josul paginii.

Nascut(a) in: 1967

Interese: microRNAs, hypoxia, cancer

flag Detalii:
American Cancer Society Research Scholar

flag Details:
Past Positions:
Molecular Oncology Research Insitute,
Tufts University and New England Medical Center,
Assistant Professor of Medicine
Investigator (2003-2008)

Dana-Farber Cancer Institute, Harvard Medical School, postdoctoral research fellow, instructor in medicine (1998-2002).

University of Wales College of Medicine, Cardiff, UK. PhD 1997, molecular mecanisms of thyroid cancer

"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania: MD degree 1993


Research focus: molecular mechanisms of oxygen sensing, microRNAs



Selected publications:

Shao M, Rossi S, Chelladurai B, Ntukogu O, Ivan M , Calin GA, Matei DE. PDGF Induced MicroRNA Alterations in Cancer Cells, Nucl Acid Res 2011.

Devlin C, Simona Greco S, Fabio Martelli F, Ivan M. miR-210: More than a Silent Player in Hypoxia. IUBMB Life, 2011

Cortez MA, Ivan C, Zhou P, Xue Wu, Ivan M, Calin GA. microRNAs in Cancer: From Bench to Bedside. Adv Cancer Res 2010, 2010;108:113-57

Rao X, Di Leva G, Li M, Fang F, Devlin CM, Hartman-Frey C, Burow ME, Ivan M, Croce CM, Nephew KP. MicroRNA-221/222 Confers Breast Cancer Fulvestrant Resistance by Regulating Multiple Signaling Pathways. Oncogene 2010 PMID: 21057537.

Ivan M, Matei, DE. Blockade of FGF Signaling: Therapeutic Promise for Ovarian Cancer. Cancer Biol Ther 2010 Sep 15;10 (5), 505-508.

Favaro E, Ramachandran A, McCormick R, Gee H, Blancher C, Crosby M, Devlin C, Blick C, Buffa F, Li J-L, Vojnovic B, Pires de Neves R, Glazer P, Iborra F, Ivan M, Ragoussis J, Harris AL. MicroRNA-210 Regulates Mitochondrial Free Radical Response to Hypoxia and Krebs Cycle in Cancer Cells by Targeting Iron Sulfur Cluster Protein ISCU. PLoS ONE 2010 Apr26 5(4): e10345;

Fasanaro P, Greco S, Ivan M, Capogrossi MC, Martelli F. microRNA: emerging therapeutic targets in acute ischemic diseases. Pharmacology & Therapeutics 2010 Jan;125(1):92-104. Epub 2009 Nov 6;

Crosby ME, Glazer PM, Ivan M. “Micro”-management of DNA Repair Genes by Hypoxia. Cell Cycle 2009 Dec 15;8(24):4009-10. Epub 2009 Dec 30

Fasanaro P, Greco S, Lorenzi M, Pescatori M, Brioschi M, Kulshreshtha R, Banfi C,Stubbs A, Calin GA, Ivan M, Capogrossi MC, Martelli F. An integrated approach for experimental target identification of hypoxia-induced miR-210. J.Biol.Chem 2009 Dec 11; 284(50):35134-43. Epub 2009 Oct 13.

Crosby ME, Devlin CM, Glazer PM, Calin GA, Ivan M. Emerging Roles of microRNAs in the Molecular Responses to Hypoxia. Curr. Pharm. Des. 2009 15(33):3861-3866.


Crosby ME, Kulshreshtha R, Ivan M, Glazer PM. microRNA Regulation of DNA Repair Gene Expression in Hypoxic Stress. Cancer Res. 2009 Feb 1;69(3):1221-9. Epub 2009 Jan 13

Ivan M, Harris AL, Martelli F, Kulshreshtha R.Hypoxia Response and microRNAs: No Longer Two Separate Worlds. J Cell Mol Med. 2008 Jun 23.

Borger DR, Gavrilescu LC, Bucur MC, Ivan M, Decaprio JA. AMP-activated protein kinase is essential for survival in chronic hypoxia. Biochem Biophys Res Commun. 2008 May 30;370(2):230-4. Epub 2008 Mar 24.


Kulshreshtha R, Ferracin M, Negrini M, Calin GA, Davuluri RV, Ivan M. Regulation of microRNA expression: the Hypoxic Component. Cell Cycle 2007 Jun 15; 6(12): 1426-31.

Fabbri M, Ivan M, Cimmino A, Negrini M, Calin GA. Expert Opin Biol Ther. 2007 Jul;7 (7): 1009-1019. Regulatory mechanisms of microRNAs involvement in cancer.


Black TM, Andrews CL, Kilili G, Ivan M, Tsichlis PN, Vouros P. Characterization of Phosphorylation Sites on Tpl2 Using IMAC Enrichment and a Linear Ion Trap Mass Spectrometer. Journal of Proteome Research 2007. J Proteome Res. 2007 May 2; [Epub ahead of print].

Kulshreshtha R, Ferracin M, Wojcik SE, Garzon R, Alder H, Agosto-Perez FJ, Davuluri R, Liu C-G, Croce CM, Negrini M, Calin GA, Ivan M. A MicroRNA Signature of Hypoxia. Mol. Cell. Biol. 2007 Mar;27(5):1859-67. Epub 2006 Dec 28.

Fernandes AF, Guo W, Zhang X, Gallagher M, Ivan M, Taylor A, Pereira P, Shang F. Proteasome-dependent regulation of signal transduction in retinal pigment epithelial cells. Exp. Eye Res. 2006 Dec;83(6):1472-81. Epub 2006 Oct 5

Yan Q, T Kamura T, Cai Y, Jin J, Ivan M, Mushegian A, Conaway RC, Conaway JW. Identification of Elongin C and Skp1 sequences that determine cullin selection. J Biol. Chem. 2004 Oct 8;279(41):43019-26.


Ivan M, Haberberger T, Gervasi DC, Michelson KS, Gunzler V, Kondo K, Yang H, Sorokina I, Conaway RC, Conaway JW, Kaelin WG Jr
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor.
Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13459-64

Min JH, Yang H, Ivan M, Gertler F, Kaelin Jr WG, Pavletich NP. Structure of an HIF-1{alpha}-pVHL Complex: Hydroxyproline Recognition in Signaling.
Science. 2002 May 9 [epub ahead of print]

Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, Salic A, Asara JM, Lane WS, Kaelin WG Jr.
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.Science. 2001 Apr 20;292(5516):464-8

Ivan M, Kaelin WG Jr.
The von Hippel-Lindau tumor suppressor protein.
Curr Opin Genet Dev. 2001 Feb;11(1):27-34.

Hoffman MA, Ohh M, Yang H, Klco JM, Ivan M, Kaelin WG Jr.
Von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF. Hum Mol Genet. 2001 1;10(10):1019-27.

Ohh M, Park CW, Ivan M, Hoffman MA, Kim TY, Huang LE, Pavletich N, Chau V, Kaelin WG.
Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat Cell Biol. 2000 Jul;2(7):423-7.

Jones CJ, Kipling D, Morris M, Hepburn P, Skinner J, Bounacer A, Wyllie FS, Ivan M, Bartek J, Wynford-Thomas D, Bond JA.
Evidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cells. Mol Cell Biol. 2000 Aug;20(15):5690-9.

Ludgate M, Gire V, Crisp M, Ajjan R, Weetman A, Ivan M, Wynford-Thomas D.
Contrasting effects of activating mutations of GalphaS and the thyrotropin receptor on proliferation and differentiation of thyroid follicular cells. Oncogene. 1999 Aug 26;18(34):4798-807.

Ivan M, Bond JA, Prat M, Comoglio PM, Wynford-Thomas D.
Activated ras and ret oncogenes induce over-expression of c-met (hepatocyte growth factor receptor) in human thyroid epithelial cells.
Oncogene. 1997 May 22;14(20):2417-23.

Publicații selectate:

* Devlin CM, Tim Lahm T, Hubbard WC, Van Demark M, Wang K, Wu X, Bielawska A, Obeid L, Ivan M, Petrache I, A Dihydroceramide-Based Response to Hypoxia, J Biol Chem, 286 (44), 2011.

* Kumar K, Wigfield S, Gee HE, Devlin CM, Singleton D, Li JL, Buffa F, Huffman M, Sinn AL, Silver J, Turley H, Leek R, Harris AL, Ivan M., Dichloroacetate Reverses the Hypoxic Adaptation to Bevacizumab and Enhances its Antitumor Effects in Mouse Xenografts, J Mol Med, 91(6), 2013.

* Crosby ME, Kulshreshtha R, Ivan M, Glazer PM, microRNA Regulation of DNA Repair Gene Expression in Hypoxic Stress, Cancer Res, 69, 2009.

* Kulshreshtha R, Ferracin M, Wojcik SE, Garzon R, Alder H, Agosto-Perez FJ, Davuluri R, Liu CG, Croce CM, Negrini M, Calin GA, Ivan M., A MicroRNA Signature of Hypoxia., Molecular and Cellular Biology, 2006.

* Ivan M, Haberberger T, Gervasi DC, Michelson KS, Gunzler V, Kondo K, Yang H, Sorokina I, Conaway RC, Conaway JW, Kaelin WG Jr, Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor, Proc Natl Acad Sci U S A, 99, 2002.

* Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, Salic A, Asara JM, Lane WS, Kaelin WG Jr., HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing, Science, 292(5516), 2001.

Mai jos este tabelul ResearcherID/A-8109-2012 pentru toate articolele cercetatorului Mircea Ivan: