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Plasma membrane potential interferes with the respiratory burst of peripheral granulocytes

Domenii publicaţii > Biologie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Livescu A, Manda G, Constantin C, Neagu M, Iordachescu D

Editorial: journal of Cellular and Molecular Medicine, 7(1), p.73-78, 2003.


Membrane potential is involved in the regulation of several immune functions developed by granulocytes. The Na+/K+ gradient across the plasma membrane, mainly generated by the Na+/K+ pump, plays a key role in the maintenance of membrane potential. This study is focused on the correlation between plasma membrane potential and the in vitro receptor – triggered respiratory burst of normal human peripheral granulocytes. The respiratory burst was measured as superoxide anion release by the cytochrome c reduction test and plasma membrane potential was modulated by experimental changes of the extracellular potassium concentration. Results show a differentiated cellular response, depending on the in vivo activation state and on the signals received in vitro by granulocytes via CR3 or FcR. Alteration of the membrane potassium gradient modulates the respiratory burst of unstimulated and CR3-activated cells, whilst it does not seem to significantly interfere with the signals delivered by FcR.

Cuvinte cheie: Granulocytes, respiratory burst, superoxide anion, plasma membrane potential