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Endoplasmic reticulum stress and the on site function of resident PTP1B

Domenii publicaţii > Biologie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Doina Popov

Editorial: Biochemical and Biophysical Research Communications, 422, p.535-538, 2012.

Rezumat:

Growing evidence links the stress at the endoplasmic reticulum (ER) to pathologies such as diabetes mellitus,
obesity, liver, heart, renal and neurodegenerative diseases, endothelial dysfunction, atherosclerosis,and cancer. Therefore, identification of molecular pathways beyond ER stress and their appropriate modulation might alleviate the stress, and direct toward novel tools to fight this disturbance. An interesting resident of the ER membrane is protein tyrosinephosphatase 1B (PTP1B), an enzyme that negatively regulates insulin and leptin signaling, contributing to insulin and leptin resistance. Recently, new functions
of PTP1B have been established linked to ER stress response. This review evaluates the novel data on ER
stressors, discusses the mechanisms beyond PTP1B function in the ER stress response, and emphasizes the potential therapeutic exploitation of PTP1B to relieve ER stress.

Cuvinte cheie: UPR, rezistenta la insulina, rezistenta fata de leptina,obezitatea, diabetul zaharat // Unfolded Protein Response (UPR), Insulin resistance, Leptin resistance, Obesity, Diabetes mellitus

URL: http://dx.doi.org/10.1016/j.bbrc.2012.05.048