Asymmetric allylic alkylation leading to dimethyl [(2E)-1,3-diphenylprop-2-en-1-yl]propanedioate 1 is a privileged reaction which has been considered in more than 800 references from 1985 to early 2012. This paper thus begins with a thorough review of the literature with a particular focus on the way the ee's and absolute configuration of the prevailing enantiomer were claimed and reported by the authors. In a large majority of articles chiral chromatography

The structures and absolute configurations of the enantiomers (3aR,8aR)-2,2-dimethyl-4,4,8,8-tetraphenyl-4,5,6,7,8,8a-hexahydro-3aH-1,3-dioxolo[4,5-e][1,3]diazepin-6-one 0.33-hydrate, C32H30N2O(3)center dot 0.33H2O, (Ia), and (3aS,8aS)-2,2-dimethyl-4,4,8,8-tetraphenyl-4,5,6,7,8,8a-hexahydro-3aH-1,3-dioxolo[4,5-e][1,3]diazepin-6-one 0.39-hydrate, C32H30N2O(3)center dot 0.39H2O, (Ib), have been elucidated unambiguously using the complementary power

Open postdoctoral positions at the Scripps Research Institute (La Jolla and Florida) in the following areas: Cancer Biology Cell Biology Chemical Physiology Chemistry Committee on the Neurobiology of Addictive Disorders Genetics Immunology & Microbial Science Infectology Metabolism & Aging Molecular & Experimental Medicine (MEM) Molecular & Integrative Neurosciences (MIND) Molecular Biology Molecular Therapeutics Neurobiology Neuroscience The Skaggs

New chiral enantiopure ureas and thioureas with (R,R)-TADDOL backbone were synthesized. Bis-(thio)ureas with C2 symmetry were obtained from TADDOL iso(thio)cyanates and bifunctional amino-(thio)ureas from TADDAMINE, respectively. These were tested for carboxylate recognition capacity and the association constant was determined for the most stable complex.

A homologous series of chiral bis-ketals and mixed hemiketal-ketals with rigid bicyclo[3.3.1]-3,7-dioxanonane skeleton has been prepared. The crystallization mode (conglomerate or racemic compound) was established by chiral HPLC with double UV/polarimetric detection. The study of the solid-state structure by single crystal X-ray diffraction disclosed interesting CHcdots, three dots, centeredπ intermolecular interactions. Hindering of rotation of

Six enantiomeric pairs of TADDOL-s gathered in two series with either methyl (series A) or phenyl (series B) substituent in 2-position of the dioxolane ring were studied by vibrational circular dichroism (VCD). Experimental IR and VCD spectra associated with density functional theory (DFT) calculations showed that the two series exhibit quite different conformations in solution. In series A, the conformer with anti CO bonds and stabilized by intramolecular

A sensitive biosensor for chloropyrifos (CPF), an organophosphorus pesticide, was developed by immobilizing acetylcholinesterase (AChE) through covalent bonding to an oxidized exfoliated graphite nanoplatelet (xGnPs)–chitosan cross-linked composite. Because of the increased surface area and the conductive properties of the nanomaterial, AChE developed a high affinity for acetylthiocholine (ATCI) and formed thiocholine with a fast response. The

Trends and perspectives of the IR/VCD chiroptical technique in onfigurational and conformational assignment of chiral compounds are illustrated with significant examples from literature reports within 2003-2008 period. The advantages, as well as inherent imitations of VCD as complementary or competing technique to the classical chiroptical methods are underlined.

n conglomerates, each single crystal contains only one of the two possible enantiomeric forms - either dextrorotatory or levorotatory. The analysis of a single crystal by liquid chromatography on chiral support associated with chiroptical detection is a very efficient tool to reveal the occurrence of a conglomerate. In terms of rapidity and easiness, this method compares favorably with the classical methods used to show this occurrence. Two examples