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The design of leadlike combinatorial libraries.

Domenii publicaţii > Chimie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Teague, Simon J.; Davis, Andrew M.; Leeson, Paul D.; Oprea, Tudor I.

Editorial: Angew. Chem., Int. Ed., 38(24), p.3743-3748, 1999.


A review with 26 refs. The authors proposed that the properties required of library compds. intended to provide leads suitable for further optimization may be rather different. The selection of leadlike compds. for further optimization eases the pressure on subsequent and more labor-intensive parts of drug discovery process.

Cuvinte cheie: Combinatorial library, Drug Design, Drug Discovery, Drug screening, High-throughput screening, HTS, QSAR, Structure-activity relationship