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Nitrate esters as nitric oxide donors: SS-nitrates

Domenii publicaţii > Ştiinţe medicale + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Zavorin, S.I., Artz, J.D., Dumitrascu, A., Nicolescu, A.C., Scutaru, D., Smith, S.V., Thatcher, G.R

Editorial: Org. Lett., 3(8), p.1113 -1116, 2001.


The important biological secondary messenger NO can be generated from exogenous nitrovasodilators and NO donors. Nitrate esters are nitrovasodilators and NO mimetics, believed to be biotransformed to NO in vivo. On the basis of a mechanistic hypothesis, nitrates have been synthesized that release NO at significant rates in neutral aqueous solution in the presence only of added thiol. The novel masked -mercaptonitrates reported (SS-nitrates), provide information on possible sulfhydryl-dependent biotransformation mechanisms for nitrates in clinical use.

Cuvinte cheie: nitric oxide, organic nitrates, vasodilators