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The sulfamate functional group as a new anchor for solid-phase organic synthesis

Domenii publicaţii > Chimie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Ciobanu LC, Maltais R, Poirier D.

Editorial: Organic Letters, Feb 24 2(4), p.445-448, 2000.


Sulfamate derivatives were loaded on trityl chloride resin, and two variants of cleavage were developed for this sulfamate anchor: an acid treatment to easily restore the free sulfamate and a nucleophilic treatment to generate the corresponding phenol. In addition to loading/cleavage assays and stability experiments, a model sequence of reactions was performed with the new sulfamate anchor to show its applicability in further combinatorial solid-phase synthesis of libraries of biologically relevant sulfamate derivatives.

Cuvinte cheie: sulfamate, solid phase organic synthesis