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Simulated effects of inhomogeneities of ventricular repolarization on the electrocardiogram

Domenii publicaţii > Ştiinţe medicale + Tipuri publicaţii > Articol în volumul unei conferinţe

Autori: A.D. Corlan

Editorial: Electrocardiology'2000, p.91-96, 2000.


The purpose of this study was to explore the link between various
types of repolarization heterogeneities and
electrocardiographic indices previously proposed for estimating them. Models of both ventricles with a spectrum of values for transmural
gradient of action potential duration (APd), longitudinal gradient and
interventricular gradient were generated as well as localised changes
of APd in the free left ventricular wall. A spherical lead system was used.

The transmural gradient was the main determinant of the
repolarization potentials and was proportional to the stability of the
repolarization pattern. The APd difference between the right and the
left ventricle and the longitudinal gradient has an opposite but slight
influence, except when the transmural gradient was low. The
localised changes produced inconsistent changes of the repolarization
heterogeneity indices.

Some indices are more specific to global gradient changes while other
to local heterogeneities. The interpretation of the later compared
to normal values predicted by the former could improve their practical

Cuvinte cheie: repolarizare ventriculara, predictia aritmiilor maligne, problema directa a electrocardiografiei, modelare computerizata // ventricular repolarization, malignant arrhymia prediction, forward problem of electrocardiography, computer modelling