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EPR investigation of gamma-irradiated anti-emetic drugs

Domenii publicaţii > Fizica + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: G.Damian

Editorial: G.D. Christian, J.-M. Kauffmann, Elsevier, Talanta, 60, p.923-927, 2003.

Rezumat:

Electron paramagnetic resonance spectroscopy was used to investigate the γ-radiation damage in the microcristalline powder form of two antiemetic drugs, namely 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy benzamide monohydrochloride monohydrate (metoclopramide) and 9-tetrahydro-9-methyl-3-[( 2-methyl-1H-imidazol-1-yl) methyl]-4H-carbazol-4-one, monohydrochloride, dihydrate (odansetron). EPR measurements proved that both of them contained various stable paramagnetic species after irradiation and relative yielding of the free radicals depends on the adsorbed dose. The metoclopramide drug exhibited very weak EPR signals before irradiation. Some spectroscopic properties and suggestions concerning possible structure of the radicals are discussed in this paper

Cuvinte cheie: spectroscopie EPR, iradiere γ, metoclopramid, odansetron // EPR spectroscopy, γ-irradiation, metoclopramide, odansetron