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New Nano-Sized Sensing Drug and Its Clinical Application

Domenii publicaţii > Ştiinţe medicale + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Rodica-Mariana Ion, Dragos-Viorel Brezoi

Editorial: Trans Tech Publications, Switzerland, Solid State Phenomena, Vol. 106, p.79-82, 2005.


Nanomedicine is the application of nanotechnology to the diagnosis and treatment of
human disease. This discipline has the potential to change medical science dramatically, for
example as demonstrated by an innovation in cancer imaging that uses novel diagnostic agents
synthesized from nanoparticles. Some research on cluster-based materials for future medical
applications is described in this paper. The design of a multifunctional photosensitive particle that
is stable and highly efficient will be key to this novel medical application and especially in
photodynamic treatment (PDT). Three consecutive processes occur during the PDT treatment:
initial consumption of oxygen through the photodynamic process; pathophysiologic alterations in
regional blood supply (hypoxia) and total vascular occlusion (ischemia). The effect of a new drug
TiO2/TSPP was studied work. Cancer cells were implanted under the skin of mice to cause tumors.
When the size of the tumor grew to about 0.5 cm, it was injected a solution containing fine particles
of TiO2/TSPP. After 2 or 3 days, the skin was cut to expose the tumor and irradiated. The
treatment clearly inhibited the tumor growth. A further marked antineoplastic effect was obtained.

Cuvinte cheie: porfirine, AFM, tratament fotodinamic, TiO2, TSPP // porphyrins, AFM, photodynamic treatment,TiO2, TSPP.