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New sulphonamides with acridinic nucleus

Domenii publicaţii > Chimie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Ferencz, L, Farcasan, V, Silberg, IA

Editorial: Revue Roumaine de Chimie, 48 (10), p.801-811, 2003.


Sixteen new sulphonamides with acridonic, acridanic and acridinic nucleus were synthesised, in which the sulphonamidic group appears in positions 1, 2, 3 and 4.
We proved that in the case of 2-nitroacridone synthesis, by ring closure of 4-nitrodiphenylamine-2-carboxylic acid, working in presence of sulphuric acid, sulphonation takes place.
To reduce some nitroacridones we used hydrazine hydrate in the presence of Ni from formiate and Ni Raney, a method not yet mentioned in the literature for compounds of this class, and which presents many advantages.
We proved that sulphonamides with acridonic nucleus can be transformed into the corresponding acridines, by reduction with Na-amalgam.
The studied new substances show a noteworthy activity against microorganisms.

Cuvinte cheie: acridine, acridone, acridane, sulphonamides, nitroacridone, aminoacridone