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Adsorption behavior of hyaluronidase onto silver nanoparticles and PMMA bone substitute

Domenii publicaţii > Fizica + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Cavalu, S. Cinta Pinzaru, N. Peica, G. Damian, W. Kiefer

Editorial: INOE&INFM, Journal of Optoelectronics and Advanced Materials, 9(3), p.689-692, 2007.


Surface enhanced Raman scattering (SERS) and ATR-FTIR spectroscopy was applied in this work, in order to get
information about the adsorption behavior of the title macromolecule with respect to different surfaces. In this case, the silver substrate can be considered as artificial substrate and the investigations regarding the mechanisms of adsorption can be useful in order to elucidate the active site properties of this enzyme. Our purpose is to study the adsorption mechanism
of hyaluronidase onto silver nanoparticles and PMMA (polymethyl methacrylate) substrates as well as qualitative and quantitative aspects regarding perturbations of protein secondary structure (alpha-helix, beta-sheet and unordered structures) upon
adsorption, using deconvolution techniques.

Cuvinte cheie: SERS, Raman, FTIR, Hyaluronidase adsorption, Conformational change