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Bridging biomolecules with nanoparticles: surface-enhanced Raman scattering from colon carcinoma and normal tissue

Domenii publicaţii > Fizica + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: S. Cinta Pinzaru, L. M. Andronie, I. Domsa, O. Cozar and S. Astilean

Editorial: Wiley InterScience, Journal of Raman Spectroscopy, 39(3), p.331, 2008.


In order to get insight into the chemical heterogeneities of solid tumors, here we report the first surfaceenhanced
Raman scattering (SERS) experiment from normal and altered epithelial layer in human colon
carcinoma tissues. The Ag colloidal nanoparticles that can be incorporated into the interstitial space in
solid tumors or those penetrating into cytoplasm or nucleus of many cells allowed high quality SERS
signal. Different tissue structures of tumor and normal colon have characteristic features in SERS spectra.
Prominent SERS features of malignant tissue spectra are related to the strong enhancement of the bands
preponderantly attributable to DNA or RNA bases. The preliminary studies demonstrate that it is possible
to probe Ag colloidal nanoparticles adsorption onto the tissue resulting in a strong molecular signaling
with high specificity and rapid acquisition time using visible laser line excitation. Copyright  2008 John
Wiley & Sons, Ltd.

Cuvinte cheie: micro-Raman; SERS; Ag nanoparticles; colon tissues; adenocarcinoma