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Chemical structure of Methylmethacrylate-2-[2′,3′,5′-triiodobenzoyl]oxoethyl methacrylate copolymer, radio-opacity, in vitro and in vivo biocompatibility

Domenii publicaţii > Ştiinţe medicale + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Catalin ZAHARIA, Teodora ZECHERU, Marie Françoise MOREAU,Florence PASCARETTI-GRIZON, Guillaume MABILLEAU, Bogdan MARCULESCU, Robert FILMON, Corneliu CINCU, Georges STAIKOS, Daniel CHAPPARD

Editorial: Acta Biomaterialia, doi:10.1016/j.actbio.2008.06.009 online, 2008.


The properties of copolymers (physical, chemical, biocompatibility, etc.) depend on their chemical structure and micro structural characteristics. We have prepared radio-opaque polymers based on the copolymers of methyl methacrylate (MMA) and 2-[2′,3′,5′-triiodobenzoyl]oxoethyl methacrylate (TIBOM). The copolymerization reaction between TIBOM and MMA showed that the reactivity ratios were r1= 0.00029 and r2=1.2146. The composition diagram is typical for a practically non-homopolymerizable monomer (TIBOM) and a very reactive monomer (MMA). The copolymers were analyzed on an X-ray micro computed tomograph and they proved to be radio-opaque even at low concentration of TIBOM. The biocompatibility was tested both in vitro (with J774.2 macrophage and SaOS-2 osteoblast like cells) and in vivo in the rat. These materials were found not toxic and were well tolerated by the organism. These combined results obtained lead to the suggestion that this type of polymers could be used as dental or bone cements for the replacement of barium or zirconium particles usually added to provide X-ray opacity.

Cuvinte cheie: iodine-containing polymers, pMMA, radio-opacity, microCT, biocompatibility, cement.