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Biological effect of some new pyridazine derivatives on wheat in germination experiments

Domenii publicaţii > Chimie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Butnariu-Tucaliuc, R., Risca, I. M., Drochioiu, G. and Mangalagiu, I

Editorial: Roum. Biotechnol. Lett., 13(4) , p.3837-3842, 2008.


Pyridazine compounds have an intense biological activity, being used as anticancer, antituberculosis, antihypertensive, antifungal, or antimicrobial agents. Nevertheless, some of them might be noxious persistent compounds to the environment. Therefore, several studies to test the biologic effect of some new pyridazine derivatives have been done using simple experiments of wheat germination. The germination percentage, shoot and root length, fresh weights, as well as free amino
acid content varied as a function of concentration and structure of each investigated compound. Triplicate of 50 seed samples of wheat were treated with 5∙10 -3 molar solutions of both pyridazinium bromides (2ac) and the corresponding cycloadducts (49) for 1 hour. After a 7 day period of germination in the presence of the investigated compound, the wheat plantlets were cut from the seeds. The total height (H) of the lots and the weight (W) of the seedlings, as well as the free amino acids were measured. Among the pyridazine derivatives, the fluorinecontaining 6a proved to be the
most toxic, whereas another fluorinated compound, 9a, exhibited even a slight stimulatory action on the germination process. All the other tested compounds displayed a large variety of biological

Cuvinte cheie: biological activity, pyridazine cycloadducts, monoquaternary salts, wheat germination, free amino acids, germination rate