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Synthetic cysteine-peptide and its relation with heavy and radioactive metals

Domenii publicaţii > Chimie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Murariu, M., Popa, K., Dragan, E. S., Drochioiu, G.

Editorial: Rev. Roum. Chim., 54(8), p.741-747, 2009.


The development of radio protective agents with lower toxicity and an extended window of protection has attracted much attention. Glutathione and a new synthesized decapeptide (P10) were used to investigate the protective effect of cysteine peptides. Besides, P10 was characterized by mass spectrometry, atomic force microscopy and circular dichroism spectroscopy. Then, the accumulation and the effect of radioactive mercury on wheat seedlings (Triticum aestivum L.) were determined in the course of germination. The radioactive mercury accumulated especially in roots
and less in shoots; sugars seem to be the most important in the 203Hg2+ accumulation. Glutathione diminished the
radiotoxic effect of 203Hg as shown by the shoot weight and length of the lots (1.79 g and 310.2 cm in the case of
glutathione and 203Hg versus 1.56 g and 249.0 cm for the 203Hg treatment). Cystine had also a powerful protective
effect, whereas the synthetic decapeptide proved to be harmful in wheat germination experiments.

Cuvinte cheie: Peptide synthesis, Mass spectrometry, Circular dichroism, Atomic force microscopy, Mercury-203, Radiotoxicity, Glutathione