Inscriere cercetatori

Premii Ad Astra

premii Ad Astra

Asociația Ad Astra anunță lansarea proiectului Premiilor Ad Astra 2022 (link aici), care își propune identificarea și popularizarea modelelor de succes, a rezultatelor excepționale ale cercetătorilor români din țară și din afara ei. Regulamentul de participare se poate gasi aici, iar  pagina de inscriere se poate accesa aici.

Asociatia Ad Astra a cercetatorilor romani lanseaza BAZA DE DATE A CERCETATORILOR ROMANI DIN DIASPORA. Scopul acestei baze de date este aceea de a stimula colaborarea dintre cercetatorii romani de peste hotare dar si cu cercetatorii din Romania. Cercetatorii care doresc sa fie nominalizati in aceasta baza de date sunt rugati sa trimita un email la cristian.presura@gmail.com

Hydractinia echinata test system. II. SAR toxicity study of some anilide derivatives of Naphthol-AS type

Domenii publicaţii > Chimie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Chicu, Sergiu Adrian; Funar-Timofei, Simona; Simu, Georgeta-Maria

Editorial: 82 (11), p.1578-1582, 2011.

Rezumat:

In this paper, a toxicity study for a series of anilides of Naphthol-AS type is presented. The toxicity of the model compounds was determined by using the Hydractinia echinata (Hydrozoa) test system. Conformational analysis of Naphthol-AS derivatives was performed to elucidate the possible enzymatic hydrolysis mechanism of these compounds. This mechanism occurs with different rates and always leads to a stoichiometric mixture of reaction products, consisting in the substituted amine and the corresponding α-hydroxy-carboxylic acid. With one exception, the toxicities of the reaction products are subadditive. Quite similar measured toxicity values, log(1/MRC50), led to their average calculated values, and thus to the establishment of class isotoxicity. This method represents a practical alternative useful for the reduction of experimental tests on animals to the lowest possible level, in accordance to the ‘3Rs’ (reduction, refinement and replacement) concept.

Cuvinte cheie: Hydractinia echinata; Naphthol-AS; Class isotoxicity; Omega software; Conformational analysis

URL: http://www.sciencedirect.com/science/article/pii/S0045653510013640